3,3'-difluorobenzaldazine

a selective positive allosteric modulator of mGluR5 activity; structure in first source

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

1.	Traumatic Brain Injuries (Traumatic Brain Injury) 01/01/2014 - "To address such concerns, we evaluated the anti-inflammatory activities of several positive allosteric modulators using various in vitro assays, and found that 3,3'-difluorobenzaldazine, 3-cyano-N-(1,3-diphenyl-1H-pyrazol- 5-yl)benzamide and 4-nitro-N-(1-(2-fluorophenyl)-3-phenyl-1H-pyrazol-5-yl)benzamide showed significantly improved potency which makes them potential lead compounds for further development of positive allosteric modulators for the treatment of traumatic brain injury."
2.	Hyperkinesis 05/01/2008 - "The purpose of this study was to examine whether CHPG and positive allosteric modulator 3,3'-difluorobenzaldazine (DFB) can reverse ketamine-induced behavioral responses including locomotor hyperactivity, motor incoordination, sensorimotor gating deficit, and learning impairment. "
3.	Ataxia (Dyssynergia) 05/01/2008 - "The purpose of this study was to examine whether CHPG and positive allosteric modulator 3,3'-difluorobenzaldazine (DFB) can reverse ketamine-induced behavioral responses including locomotor hyperactivity, motor incoordination, sensorimotor gating deficit, and learning impairment. "

1.	4- nitro- N- (1- (2- fluorophenyl)- 3- phenyl- 1H- pyrazol- 5- yl)benzamide
2.	Ketamine