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alternagin-C

a nonRGD-disintegrin, induces neutrophil migration via integrin signaling

Also Known As:

Alt-C, disintegrin

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Disintegrins: 1685
    - alternagin-C: 5

Experts

1.	Moritz, Milene Nóbrega de Oliveira: 2 articles (04/2022 - 01/2018)
2.	Dos Santos, Patty Karina: 2 articles (11/2019 - 01/2018)
3.	Casali, Bruna Carla: 1 article (04/2022)
4.	Karina Dos Santos, Patty: 1 article (04/2022)
5.	Selistre-de-Araujo, Heloisa Sobreiro: 1 article (04/2022)
6.	Stotzer, Uliana Sbeguen: 1 article (04/2022)
7.	Andrade, Silvia Passos: 1 article (11/2019)
8.	Araújo, Fernanda de Assis: 1 article (11/2019)
9.	Deconte, Simone Ramos: 1 article (11/2019)
10.	Ferreira, Bruno Antonio: 1 article (11/2019)

Related Diseases

1.	Inflammation (Inflammations) 11/01/2019 - "Alternagin-C, a disintegrin-like protein from Bothrops alternatus venom, attenuates inflammation and angiogenesis and stimulates collagen deposition of sponge-induced fibrovascular tissue in mice." 04/30/2022 - "Alternagin-C (ALT-C), a disintegrin-like protein purified from Bothrops alternatus venom, binds to α2β1 integrin, attenuating inflammation and angiogenesis, and decreasing metalloprotease levels in the tumor microenvironment, which suggests anti-metastatic effects. " 11/01/2019 - "Alternagin-C (ALT-C), a disintegrin-like protein obtained from the venom of Bothrops alternatus, is able to modulate cellular behaviors such as adhesion, migration and proliferation, as well as the production of various growth factors via α2β1 integrin, important processes during inflammation, angiogenesis and fibrogenesis, which although appear as distinct events, act concomitantly in several chronic inflammatory diseases. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2018 - "Alternagin-C binding to α2β1 integrin controls matrix metalloprotease-9 and matrix metalloprotease-2 in breast tumor cells and endothelial cells." 04/30/2022 - "Alternagin-C, an alpha2beta1 integrin ligand, attenuates collagen-based adhesion, stimulating the metastasis suppressor 1 expression in triple-negative breast tumor cells."
3.	Wounds and Injuries (Trauma) 11/01/2008 - "Angiogenesis and growth factor modulation induced by alternagin C, a snake venom disintegrin-like, cysteine-rich protein on a rat skin wound model."
4.	Neoplasm Metastasis (Metastasis) 04/30/2022 - "Alternagin-C, an alpha2beta1 integrin ligand, attenuates collagen-based adhesion, stimulating the metastasis suppressor 1 expression in triple-negative breast tumor cells."
5.	Hypoxia (Hypoxemia) 01/01/2019 - "We investigated the effects of a single dose of alternagin-C (0.5 mg kg-1, via intra-arterial), after 7 days, on hypoxia/reoxygenation challenge in isolated ventricle strips and on morphological changes and density of blood vessels of the heart, using fish as an alternative experimental model. " 01/01/2019 - "Cardioprotective effects of alternagin-C (ALT-C), a disintegrin-like protein from Rhinocerophis alternatus snake venom, on hypoxia-reoxygenation-induced injury in fish."

Related Drugs and Biologics

1.	Disintegrins
2.	Proteins (Proteins, Gene)
3.	Integrins
4.	Intercellular Signaling Peptides and Proteins (Growth Factors)
5.	Venoms
6.	Snake Venoms (Snake Venom)
7.	Collagen
8.	Metalloproteases (Metalloproteinases)
9.	Integrin alpha2beta1
10.	Ligands