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A-Z-CINN 310

a prodrug used in the treatment of HER-2-positive breast tumor cells

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - Taxoids: 2650
        Paclitaxel: 22016
        A-Z-CINN 310: 1
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclodecanes
        Taxoids: 2650
        Paclitaxel: 22016
        A-Z-CINN 310: 1

Experts

1.	Black, Kirby S: 1 article (01/2003)
2.	Gilbert, Carl W: 1 article (01/2003)
3.	McGowan, Eleanor B: 1 article (01/2003)
4.	Pegram, Mark D: 1 article (01/2003)
5.	Seery, Gerald B: 1 article (01/2003)

Related Diseases

1.

Neoplasms (Cancer)

01/01/2003 - "This suggests that targeted delivery of paclitaxel using A-Z-CINN 310 kills tumor cells by localized release of paclitaxel at the tumor site, which can be accelerated by light treatment. "
01/01/2003 - "After treatment with A-Z-CINN 310, some mice received light exposure at 6 h for 5 min adjacent to the tumor to cause light-accelerated release of paclitaxel. "
01/01/2003 - "This study demonstrates the effectiveness of a single-treatment use of A-Z-CINN 310 in decreasing tumor volume and tumor cell density of human HER-2-positive BT-474 mammary tumor cells implanted in scid mice, compared to treatment with simultaneously administered trastuzumab and paclitaxel and with saline control. "
01/01/2003 - "Animals treated with A-Z-CINN 310, then light, showed dose-dependent decreases in tumor volume and tumor cell density which were more rapid and extensive than those seen with A-Z-CINN 310 without light or a 10-fold higher concentration of co-administered trastuzumab plus paclitaxel. "

Related Drugs and Biologics

1.	Paclitaxel (Taxol)
2.	Trastuzumab (Herceptin)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)