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8- (4- fluorophenyl)- 2- (3- phenyl- 2- propenoyl)- 1,2,3,4- tetrahydropyrazolo(5,1- c)(1,2,4)triazine

a free radical scavenger with neuroprotective activity; FR-210575 is the (2E)-isomer; structure in first source

Also Known As:

FR 210575; FR-210575; FR210575

Networked: 1 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Cinnamates: 48
      - 8-(4-fluorophenyl)-2-(3-phenyl-2-propenoyl)-1,2,3,4-tetrahydropyrazolo(5,1-c)(1,2,4)triazine: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Triazines: 306
    - 8-(4-fluorophenyl)-2-(3-phenyl-2-propenoyl)-1,2,3,4-tetrahydropyrazolo(5,1-c)(1,2,4)triazine: 1

Experts

1.	Hisajima, Hiroshi: 1 article (12/2003)
2.	Iwashita, Akinori: 1 article (12/2003)
3.	Maemoto, Takuya: 1 article (12/2003)
4.	Matsuoka, Nobuya: 1 article (12/2003)
5.	Nakada, Hirohisa: 1 article (12/2003)
6.	Shima, Ichiro: 1 article (12/2003)

Related Diseases

1.	Brain Ischemia (Cerebral Ischemia) 12/01/2003 - "In the present study, the neuroprotective efficacy of FR210575 was evaluated in two neuronal death models in vitro as well as rat focal cerebral ischemia models in vivo. " 12/01/2003 - "In two models of cerebral ischemia [photothrombotic occlusion of middle cerebral artery (MCA) for transient model and by permanent MCA occlusion for permanent model], rats received 3-h intravenous infusion (1-10 mg/kg/3 h) of FR210575, with brain damage determined 24 h later. "
2.	Stroke (Strokes) 12/01/2003 - "These findings indicate that the powerful radical scavenger FR210575 has potent neuroprotective activity and that FR210575 could be an attractive candidate for the treatment of stroke or other neurodegenerative disorders."
3.	Neurodegenerative Diseases (Neurodegenerative Disease) 12/01/2003 - "These findings indicate that the powerful radical scavenger FR210575 has potent neuroprotective activity and that FR210575 could be an attractive candidate for the treatment of stroke or other neurodegenerative disorders."
4.	Ischemia 12/01/2003 - "A novel potent radical scavenger, 8-(4-fluorophenyl)-2-((2E)-3-phenyl-2-propenoyl)-1,2,3,4-tetrahydropyrazolo[5,1-c] [1,2,4]triazine (FR210575), prevents neuronal cell death in cultured primary neurons and attenuates brain injury after focal ischemia in rats."
5.	Brain Injuries (Brain Injury) 12/01/2003 - "A novel potent radical scavenger, 8-(4-fluorophenyl)-2-((2E)-3-phenyl-2-propenoyl)-1,2,3,4-tetrahydropyrazolo[5,1-c] [1,2,4]triazine (FR210575), prevents neuronal cell death in cultured primary neurons and attenuates brain injury after focal ischemia in rats."

Related Drugs and Biologics

1.	Triazines

Related Therapies and Procedures

1.	Intravenous Infusions