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3- (alpha- (4- allyl- 2,5- dimethyl- 1- piperazinyl)- 3- hydroxybenzyl)- N- (3- fluorophenyl)- N- methylbenzamide

an antinociceptive agent and mixed opioid agonist; DPI-3290 is the ((alpha-R),(2S,5R)-isomer); structure in first source
Also Known As:
DPI 3290; DPI-3290; DPI3290
Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. McNutt, Robert: 2 articles (12/2003 - 12/2003)
2. Chang, Kwen-Jen: 2 articles (12/2003 - 12/2003)
3. O'Neill, Scott J: 2 articles (12/2003 - 12/2003)
4. Pettit, Hugh O: 2 articles (12/2003 - 12/2003)
5. Gengo, Peter J: 2 articles (12/2003 - 12/2003)
6. Bishop, Michael J: 1 article (12/2003)
7. Wei, Ke: 1 article (12/2003)
8. Su, Ying Fu: 1 article (12/2003)

Related Diseases

1. Hypercapnia
12/01/2003 - "Furthermore, DPI-3290 reduced the alfentanil-mediated hypercapnia without any effect on antinociception. "
12/01/2003 - "Intravenous bolus doses of DPI-3290 that ranged from 0.2 to 1.0 mg/kg had no effect on antinociception mediated by alfentanil (2 microg/kg/min i.v.) but reduced hypercapnia by approximately 50%. "
12/01/2003 - "Together, the balanced opioid agonist activity of DPI-3290 may provide a means of powerful analgesia while mitigating the mu-opioid receptor-mediated hypercapnia."
12/01/2003 - "Results from these studies demonstrate the equivalent antinociceptive efficacy of DPI-3290, morphine, and fentanyl but dramatic differences in the hypercapnia that antinociceptive doses of these drugs produce. "
12/01/2003 - "Intravenous administration of DPI-3290 in conscious laboratory rats increased antinociception in a dose-dependent manner with a corresponding ED(50) value of 0.05 +/- 0.0072 mg/kg. Simultaneous measurement of arterial blood gas in animals treated with DPI-3290 demonstrated dose-dependent increases in pCO2 with an ED(50) value of 0.91 +/- 0.22 mg/kg. In comparison, morphine and fentanyl increased antinociception in rats with ED(50) values of 2.01 +/- 0.0005 and 0.0034 +/- 0.00024 mg/kg, respectively, and the ED(50) value for morphine-induced changes in pCO2 was 4.23 +/- 0.72 mg/kg, whereas the ED(50) value for fentanyl-induced changes in pCO2 was 0.0127 +/- 0.0035 mg/kg. A separate series of experiments were designed to examine the effects of DPI-3290 on mu-opioid receptor induced antinociception and hypercapnia. "
2. Pain (Aches)

Related Drugs and Biologics

1. Morphine (MS Contin)
2. Fentanyl (Sublimaze)
3. mu Opioid Receptors (mu Opioid Receptor)
4. Alfentanil (Alfenta)

Related Therapies and Procedures

1. Analgesia