|1.||Myers, Andrew G: 2 articles (03/2015 - 11/2007)|
|2.||Gjertsen, Bjørn Tore: 1 article (03/2015)|
|3.||Mukherjee, Herschel: 1 article (03/2015)|
|4.||Hanley, Mariah L: 1 article (03/2015)|
|5.||Chan, Kok-Ping: 1 article (03/2015)|
|6.||Andresen, Vibeke: 1 article (03/2015)|
|7.||Siegrist, Romain: 1 article (11/2007)|
|8.||Wulff, Jeremy E: 1 article (11/2007)|
03/20/2015 - "We also observe that avrainvillamide treatment displaces Thr199-phosphorylated NPM1 from duplicated centrosomes, leads to an accumulation of supernumerary centrosomes, and inhibits dephosphorylation of Thr199-phosphorylated NPM1 by protein phosphatase 1. Avrainvillamide is the first small molecule reported to relocalize specific cytoplasmic AML-associated NPM1 mutants to the nucleolus, providing an important demonstration of principle that small molecule induction of a wild-type NPM1 localization phenotype is feasible in certain human cancer cells."
11/21/2007 - "Using fluorescence microscopy, a synthetic dansyl-avrainvillamide conjugate was observed to localize within the nucleoli and the cytosol of treated cancer cells. "
11/21/2007 - "Here we present evidence that (+)-avrainvillamide, a naturally occurring alkaloid with antiproliferative effects, binds to the nuclear chaperone nucleophosmin, a proposed oncogenic protein that is overexpressed in many different human tumors. "
|1.||Protein Phosphatase 1
|2.||1- myristoyl- 2- (12- ((5- dimethylamino- 1- naphthalenesulfonyl)amino)dodecanoyl)- sn- glycero- 3- phosphocholine