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N-(4-ethoyphenol)-2-hydroxy- acid amide

inhibits HER-2/neu receptor tyrosine kinase phosphorylation and growth of HER-2/neu-overexpressing breast cancer cells

Also Known As:

SUCI02

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - N-(4-ethoyphenol)-2-hydroxy- acid amide: 2
- Carboxylic Acids: 973
  - Hydroxy Acids: 94
    - N-(4-ethoyphenol)-2-hydroxy- acid amide: 2

Experts

1.	Cai, Li-Ling: 2 articles (01/2006 - 08/2003)
2.	Zhu, Xiao-Feng: 2 articles (01/2006 - 08/2003)
3.	Wang, Jing-Song: 1 article (01/2006)
4.	Yang, Dajun: 1 article (01/2006)
5.	Zeng, Yi-Xin: 1 article (01/2006)
6.	Liu, Zong-Chao: 1 article (08/2003)
7.	Xie, Bing-Fen: 1 article (08/2003)
8.	Yang, Da-Jun: 1 article (08/2003)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2003 - "The aim of this study was to examine the effect of SUCI02 on HER-2/neu-overexpressing cancer cell growth. " 08/01/2003 - "MTT assay was employed to determine the growth inhibition of SUCI02 on the tumor cells. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2006 - "Systemic administration of SUCI02 in nude mice resulted in inhibition of erbB-2 tyrosine kinase phosphorylation of subcutaneous human breast cancer BT474 xenografts. " 01/01/2006 - "SUCI02 inhibits the erbB-2 tyrosine kinase receptor signaling pathway and arrests the cell cycle in G1 phase in breast cancer cells." 08/01/2003 - "SUCI02 can inhibit tyrosine phosphorylation of HER-2/neu receptor,cell proliferation of HER-2/neu-overexpressing breast cancer cells preferentially and shut down downstream HER-2/neu signal transduction." 08/01/2003 - "[SUCI02 inhibits HER-2/neu receptor tyrosine kinase phosphorylation and growth of HER-2/neu-overexpressing breast cancer cells]."

Related Drugs and Biologics

1.	Protein-Tyrosine Kinases (Tyrosine Kinase)
2.	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)
3.	ErbB-2 Receptor
4.	Tyrosine (L-Tyrosine)