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BnSP-6

a phospholipase A2 homologue from Bothrops venom; amino acid sequence in first source

Also Known As:

Lys49-phospholipase A2, BnSP-6

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Goulart, Luiz Ricardo: 2 articles (01/2019 - 01/2016)
2.	Azevedo, Fernanda Van Petten Vasconcelos: 2 articles (10/2018 - 01/2016)
3.	Lopes, Daiana Silva: 2 articles (10/2018 - 01/2016)
4.	Rodrigues, Renata Santos: 2 articles (10/2018 - 01/2016)
5.	Rodrigues, Veridiana de Melo: 2 articles (10/2018 - 01/2016)
6.	Yoneyama, Kelly Aparecida Geraldo: 2 articles (10/2018 - 01/2016)
7.	Correia, Lucas Ian Veloso: 1 article (01/2019)
8.	Costa-Cruz, Julia Maria: 1 article (01/2019)
9.	Maia, Larissa Prado: 1 article (01/2019)
10.	Rodrigues, Jéssica Peixoto: 1 article (01/2019)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2016 - "In addition, BnSP-6 caused a remarkable increase in gene expression of BRCA2 and TP53 tumor suppressors. " 01/01/2016 - "Interestingly, cytotoxic activity of BnSP-6 was significantly lower against MCF10A, a non-tumorigenic breast cell line, suggesting that this PLA2 presented a possible preference for targets in cancer cells. " 01/01/2019 - "BnSP-6, from Bothorps pauloensis snake venom, is a PLA2 with depth biochemical characterization, reporting effects against tumor cells and bacteria. " 10/15/2018 - "BnSP-6 was able to induce a higher cytotoxic and genotoxic activity in MDA-MB-231 cells, when compared to MCF10A (a non-tumorigenic breast cell line), suggesting that this protein presented a possible preference for cancer cells. "
2.	Breast Neoplasms (Breast Cancer) 10/15/2018 - "Taken together, these results indicate that BnSP-6 induces DNA damage in breast cancer cells and is an attractive model for developing innovative therapeutic agents against breast cancer." 10/15/2018 - "Herein we evaluated the genotoxic effects of BnSP-6, a Lys-49 phospholipase A2 (PLA2) from Bothrops pauloensis, on breast cancer cells. " 01/01/2016 - "This work shows the antitumoral effects of BnSP-6, a Lys 49 PLA2 isolated from Bothrops pauloensis venom, on human breast cancer MDA-MB-231 cells. " 01/01/2016 - "Human breast cancer cell death induced by BnSP-6, a Lys-49 PLA₂ homologue from Bothrops pauloensis venom." 10/15/2018 - "Genotoxic effects of BnSP-6, a Lys-49 phospholipase A2 (PLA2) homologue from Bothrops pauloensis snake venom, on MDA-MB-231 breast cancer cells."

Related Drugs and Biologics

1.	Snake Venoms (Snake Venom)
2.	Phospholipases A2 (Phospholipase A2)
3.	Venoms
4.	Proteins (Proteins, Gene)