HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

1- tert- butyl- 3- naphthalen- 1- ylmethyl- 1H- pyrazolo(3,4- d)pyrimidin- 4- ylemine

an ATP-competitive inhibitor of Ire1; structure in first source

Also Known As:

1NM-PP1

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - 1-tert-butyl-3-naphthalen-1-ylmethyl-1H-pyrazolo(3,4-d)pyrimidin-4-ylemine: 2
  - Pyrimidines: 510
    - 1-tert-butyl-3-naphthalen-1-ylmethyl-1H-pyrazolo(3,4-d)pyrimidin-4-ylemine: 2

Experts

1.	Basbaum, Allan I: 1 article (04/2009)
2.	England, Pamela M: 1 article (04/2009)
3.	Ratnam, Joseline: 1 article (04/2009)
4.	Wang, Xidao: 1 article (04/2009)
5.	Zou, Bende: 1 article (04/2009)

Related Diseases

1.	Pain (Aches) 04/29/2009 - "We report that oral administration of 1NM-PP1, at doses that blocked phosphorylation of TrkB in the spinal cord, had no effect in behavioral tests of acute heat, mechanical, or chemical pain sensitivity. " 01/01/2022 - "This study utilized transgenic TrkBF616 mice to examine the effect of pharmacogenetic inhibition of TrkB signaling, induced by treatment with 1NM-PP1 (1NMP) in drinking water for 5 days, on formalin-induced inflammatory pain, pain hypersensitivity, and locomotor dysfunction after thoracic spinal contusion. " 04/29/2009 - "Although interfering with TrkB signaling altered neither acute capsaicin nor formalin-induced pain behavior, the prolonged mechanical hypersensitivity produced by these chemical injuries was prevented by 1NM-PP1 inhibition of TrkB signaling. "
2.	Hypersensitivity (Allergy) 04/29/2009 - "However, the same pretreatment with 1NM-PP1 prevented the development of tissue- or nerve injury-induced heat and mechanical hypersensitivity. " 04/29/2009 - "Established hypersensitivity was transiently reversed by intraperitoneal injection of 1NM-PP1. " 01/01/2022 - "This study utilized transgenic TrkBF616 mice to examine the effect of pharmacogenetic inhibition of TrkB signaling, induced by treatment with 1NM-PP1 (1NMP) in drinking water for 5 days, on formalin-induced inflammatory pain, pain hypersensitivity, and locomotor dysfunction after thoracic spinal contusion. " 04/29/2009 - "Although interfering with TrkB signaling altered neither acute capsaicin nor formalin-induced pain behavior, the prolonged mechanical hypersensitivity produced by these chemical injuries was prevented by 1NM-PP1 inhibition of TrkB signaling. "
3.	Contusions 01/01/2022 - "This study utilized transgenic TrkBF616 mice to examine the effect of pharmacogenetic inhibition of TrkB signaling, induced by treatment with 1NM-PP1 (1NMP) in drinking water for 5 days, on formalin-induced inflammatory pain, pain hypersensitivity, and locomotor dysfunction after thoracic spinal contusion. "
4.	Wounds and Injuries (Trauma) 04/29/2009 - "Although interfering with TrkB signaling altered neither acute capsaicin nor formalin-induced pain behavior, the prolonged mechanical hypersensitivity produced by these chemical injuries was prevented by 1NM-PP1 inhibition of TrkB signaling. "

Related Drugs and Biologics

1.	Formaldehyde (Formol)
2.	Drinking Water
3.	Capsaicin (Zostrix)

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Oral Administration