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pleurotin

structure in first source

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 4 or More Rings Heterocyclic Compounds
    - pleurotin: 3

Experts

1.	Aldabbagh, Fawaz: 2 articles (03/2018 - 01/2016)
2.	Berezin, Andrey A: 2 articles (03/2018 - 01/2016)
3.	Carty, Michael P: 2 articles (03/2018 - 01/2016)
4.	Koutentis, Panayiotis A: 2 articles (03/2018 - 01/2016)
5.	Sweeney, Martin: 2 articles (03/2018 - 01/2016)
6.	Zissimou, Georgia A: 2 articles (03/2018 - 01/2016)
7.	Keane, Lee-Ann J: 1 article (03/2018)
8.	Mirallai, Styliana I: 1 article (03/2018)
9.	Coyle, Robert: 1 article (01/2016)
10.	Kavanagh, Paul: 1 article (01/2016)

Related Diseases

1.	Neoplasms (Cancer) 03/03/2018 - "COMPARE analysis of five-dose testing data from the NCI showed very strong correlations to the naturally occurring anti-cancer compound pleurotin. " 01/01/2016 - "Discovery of anti-cancer activity for benzo[1,2,4]triazin-7-ones: Very strong correlation to pleurotin and thioredoxin reductase inhibition." 03/01/2003 - "We have investigated whether two cancer drugs that inhibit Trx-1 signaling, PX-12 (1-methylpropyl 2-imidazolyl disulfide) and pleurotin, decrease HIF-1alpha protein levels and the expression of downstream target genes. "
2.	Renal Cell Carcinoma (Grawitz Tumor) 03/01/2003 - "PX-12 and pleurotin also decreased HIF-1alpha protein levels and HIF-1 trans-activation in RCC4 renal cell carcinoma cells that constitutively overexpress HIF-1alpha protein because of loss of the pVHL gene, indicating that HIF-1alpha is inhibited independently of the pVHL pathway. "
3.	Carcinoma (Carcinomatosis) 03/01/2003 - "Treatment of MCF-7 human breast cancer and HT-29 human colon carcinoma cells with PX-12 and pleurotin prevented the hypoxia (1% oxygen)-induced increase in HIF-1alpha protein. "
4.	Breast Neoplasms (Breast Cancer) 03/01/2003 - "Treatment of MCF-7 human breast cancer and HT-29 human colon carcinoma cells with PX-12 and pleurotin prevented the hypoxia (1% oxygen)-induced increase in HIF-1alpha protein. "
5.	Hypoxia (Hypoxemia) 03/01/2003 - "The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation." 03/01/2003 - "Treatment of MCF-7 human breast cancer and HT-29 human colon carcinoma cells with PX-12 and pleurotin prevented the hypoxia (1% oxygen)-induced increase in HIF-1alpha protein. "

Related Drugs and Biologics

1.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2.	Thioredoxin-Disulfide Reductase
3.	Thioredoxins
4.	Proteins (Proteins, Gene)
5.	Oxygen (Dioxygen)
6.	Disulfides