|1.||Gryaznov, Sergei: 5 articles (11/2005 - 05/2003)|
|2.||Pongracz, Krisztina: 4 articles (07/2004 - 05/2003)|
|3.||Chin, Allison C: 3 articles (11/2005 - 07/2003)|
|4.||Ozawa, Tomoko: 2 articles (04/2008 - 07/2004)|
|5.||Bollen, Andrew W: 2 articles (04/2008 - 07/2004)|
|6.||Deen, Dennis F: 2 articles (04/2008 - 07/2004)|
|7.||Lamborn, Kathleen R: 2 articles (04/2008 - 07/2004)|
|8.||Gryaznov, Sergei M: 2 articles (04/2008 - 07/2004)|
|9.||Harley, Calvin B: 2 articles (11/2005 - 07/2003)|
|10.||Yamashita, Yoshinori: 2 articles (07/2003 - 05/2003)|
04/01/2008 - "Thus, intranasal delivery of GRN163 readily bypassed the blood-brain barrier, exhibited favorable tumor uptake, and inhibited tumor growth, leading to a prolonged lifespan for treated rats compared to controls. "
07/01/2004 - "Lastly, when rats with larger intracerebral tumors were treated with the inhibitor, GRN163 increased animal survival times. "
07/01/2004 - "When GRN163 was infused into intracerebral U-251 MG tumors shortly after their implantation, it prevented their establishment and growth. "
07/01/2004 - "Examination of the brains revealed that GRN163 was present in tumor cells at all time points studied. "
07/15/2003 - "Tumor cells treated with GRN163 in culture underwent telomere shortening, followed by cellular senescence or apoptosis after a period of time that generally correlated with initial telomere length. "
|2.||Hepatocellular Carcinoma (Hepatoma)
11/01/2005 - "GRN163 and GRN163L were tested in preclinical studies using systemic administration to treat flank xenografts of different human hepatoma cell lines (Hep3B and Huh7) in nude mice. "
11/01/2005 - "In conclusion, our data support the development of GRN163L, a novel lipidated conjugate of the telomerase inhibitor GRN163, for systemic treatment of human hepatoma. "
11/01/2005 - "Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma."
11/01/2005 - "We evaluated the potential of two thio-phosphoramidate oligonucleotide inhibitors of telomerase, GRN163 and GRN163L, as drug candidates for the treatment of human hepatoma. "
10/01/2003 - "Effects of oligonucleotide N3'-->P5' thio-phosphoramidate (GRN163) targeting telomerase RNA in human multiple myeloma cells."
01/01/2004 - "The effects of telomerase inhibition with an oligonucleotide N3' --> P5' thiophosphoramidate (GRN163) complementary to the telomerase template region were examined on human multiple myeloma (MM) and non-Hodgkin lymphoma (NHL) cell lines, primary MM cells, and tumor xenografts. "
|4.||Brain Neoplasms (Brain Tumor)
04/01/2008 - "New therapeutic approach for brain tumors: Intranasal delivery of telomerase inhibitor GRN163."
07/01/2004 - "Fluorescein-labeled GRN163 was loaded into an osmotic minipump and infused directly into U-251 MG brain tumors over 7 days. "
07/01/2004 - "When athymic mice bearing U-251 MG human brain tumor xenografts in their flanks were treated intratumorally with GRN163, a significant growth delay in tumor size was observed (P < 0.01 in all groups) as compared to the tumor size in mice receiving a mismatched oligonucleotide or the carrier alone. "
|5.||Prostatic Neoplasms (Prostate Cancer)
|1.||Telomerase (Telomerase Reverse Transcriptase)
|5.||telomerase RNA (bTR)
|1.||Heterologous Transplantation (Xenotransplantation)