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gentiakochianin

structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Xanthenes: 65
      - Xanthones: 211
        gentiakochianin: 1

Experts

1.	Harhaji, Ljubica: 1 article (05/2008)
2.	Isakovic, Aleksandra: 1 article (05/2008)
3.	Jankovic, Teodora: 1 article (05/2008)
4.	Kostic-Rajacic, Sladjana: 1 article (05/2008)
5.	Nikolic, Zoran: 1 article (05/2008)
6.	Trajkovic, Vladimir: 1 article (05/2008)
7.	Vajs, Vlatka: 1 article (05/2008)

Related Diseases

1.

Glioma (Gliomas)

05/15/2008 - "kochiana and Gentianella austriaca revealed dihydroxylation at positions 7, 8 of the xanthonic nucleus as the key structural feature responsible for the ability of gentiakochianin to induce microtubule-associated G(2)/M cell block and apoptotic cell death in glioma cells."
05/15/2008 - "Gentiakochianin and gentiacaulein induced cell cycle arrest in G(2)/M and G(0)/G(1) phases, respectively, in both C6 rat glioma and U251 human glioma cell lines. "
05/15/2008 - "Both the xanthones reduced mitochondrial membrane potential and increased the production of reactive oxygen species in glioma cells, but only the effects of gentiakochianin were pronounced enough to cause caspase activation and subsequent apoptotic cell death. "

Related Drugs and Biologics

1.	Xanthones
2.	Caspases
3.	Reactive Oxygen Species (Oxygen Radicals)
4.	gentiacaulein