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phakellistatin 12
has antineoplastic activity; isolated from a Phakellia marine sponge; structure in first source
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Polycyclic Compounds: 6
Macrocyclic Compounds: 15
Cyclic Peptides: 530
phakellistatin 12: 1
Amino Acids, Peptides, and Proteins: 1
Peptides: 82426
Cyclic Peptides: 530
phakellistatin 12: 1
Experts
1.
Pettit, George R
: 1 article (02/2003)
2.
Tan, Rui
: 1 article (02/2003)
Related Diseases
1.
Neoplasms (Cancer)
02/24/2003 - "
A new cancer cell growth inhibitory (P388 lymphocytic leukemia ED(50) 2.8 microg/mL) cyclodecapeptide designated phakellistatin 12 (2) has been isolated as a trace (1.7 x 10(-6)% yield) constituent of the Western Pacific Ocean (Federated States of Micronesia-Chuuk) sponge Phakellia sp. Employing principally a combination of high resolution FAB with high field (500 MHz) 1H, 13C and 2-D NMR and chiral GC analyses the structure (all S chirality) cyclo-Ile-Phe-Thr-Leu-Pro-Pro-Tyr-Ile-Pro-Pro was assigned.
"
2.
Lymphoid Leukemia
02/24/2003 - "
A new cancer cell growth inhibitory (P388 lymphocytic leukemia ED(50) 2.8 microg/mL) cyclodecapeptide designated phakellistatin 12 (2) has been isolated as a trace (1.7 x 10(-6)% yield) constituent of the Western Pacific Ocean (Federated States of Micronesia-Chuuk) sponge Phakellia sp. Employing principally a combination of high resolution FAB with high field (500 MHz) 1H, 13C and 2-D NMR and chiral GC analyses the structure (all S chirality) cyclo-Ile-Phe-Thr-Leu-Pro-Pro-Tyr-Ile-Pro-Pro was assigned.
"
Related Drugs and Biologics
1.
leucyl-prolyl-proline
2.
isoleucyl-prolyl-proline