(1,2- bis(1,2- benzisoselenazolone- 3(2H)- ketone))ethane

01/01/2019 - "The organoselenium compound ethaselen (BBSKE) has been proved to be a TrxR inhibitor and inhibit various types of tumor growth. "
05/01/2009 - "Ethaselen can inhibit TrxR activity corresponding to tumor growth inhibition."
05/01/2009 - "At the end of treatment, the inhibition rates of TrxR activity in plasma and tumor were 59.2% and 15.3% in low dose ethaselen group, 68.4% and 25.8% in moderate dose ethaselen group, 68.9% and 29.8% in high dose ethaselen group. "
05/01/2009 - "The inhibition rates of tumor growth were 59.5% in low dose ethaselen group, 74.3% in moderate dose ethaselen group, and 74.9% in high dose ethaselen group. "
02/01/2017 - "In this study we explored the relationship between the ethaselen dose and TrxR activity level and the relationship between TrxR degradation and tumor apoptosis in a human lung carcinoma A549 xenograft model. "

02/01/2017 - "Ethaselen is a novel antitumor candidate that exerts potent inhibition on non-small cell lung cancer (NSCLC) by targeting TrxR. "
01/01/2014 - "In this study, we aimed to evaluate the growth inhibitory effect of the combination of ethaselen (BBSKE) and low fixed dose of selenite against A549 human non-small cell lung cancer cells in vitro. "
02/01/2017 - "Dose-biomarker-response modeling of the anticancer effect of ethaselen in a human non-small cell lung cancer xenograft mouse model."
01/01/2014 - "Synergistic effect of ethaselen and selenite treatment against A549 human non-small cell lung cancer cells."
09/25/2017 - "Synergism between thioredoxin reductase inhibitor ethaselen and sodium selenite in inhibiting proliferation and inducing death of human non-small cell lung cancer cells."

01/01/2020 - "We confirmed that the TrxR-targeting ethaselen could be a novel and effective drug for gastric cancer treatment."
01/01/2020 - "In this paper, we examined that ethaselen effectively inhibited the growth of gastric cancer cells and promoted apoptosis. "
01/01/2021 - "In our previous study, we demonstrated that ethaselen (BBSKE), an inhibitor of thioredoxin reductase, effectively inhibited the growth of gastric cancer cells and promoted apoptosis in vitro. "
01/01/2020 - "A thioredoxin reductase inhibitor ethaselen induces growth inhibition and apoptosis in gastric cancer."
01/01/2022 - "Retraction Note: Ethaselen synergizes with oxaliplatin in tumor growth inhibition by inducing ROS production and inhibiting TrxR1 activity in gastric cancer."

09/16/2009 - "In vitro hemolysis study indicated that mPEG-PLA copolymers and ethaselen-loaded polymeric micelles had no hemolytic effect on the erythrocyte. "

02/01/2017 - "In this study we explored the relationship between the ethaselen dose and TrxR activity level and the relationship between TrxR degradation and tumor apoptosis in a human lung carcinoma A549 xenograft model. "