3,4-di-O-caffeoylquinic acid

isolated from Siphonostegia chinensis

Also Known As:

3,4-DICQA; 3,4-dicaffeoylquinic acid; isochlorogenic acid B; methyl 3,5-di-O-caffeoyl quinate; methyl-3,5-di-O-caffeoylquinate; Cyclohexanecarboxylic acid, 3,4-bis(((2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl)oxy)-1,5-dihydroxy-, (1S,3R,4R,5R)-

Networked: 17 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Cinnamates: 48
      - Chlorogenic Acid: 681
        3,4-di-O-caffeoylquinic acid: 17
    - Cyclohexanecarboxylic Acids
      - Chlorogenic Acid: 681
        3,4-di-O-caffeoylquinic acid: 17

Experts

1.	Ooi, Vincent E C: 2 articles (06/2006 - 10/2005)
2.	Choi, Yoon-Hee: 1 article (06/2021)
3.	Kang, Il-Jun: 1 article (06/2021)
4.	Lee, Ji-Hyun: 1 article (06/2021)
5.	Lee, So-Yeon: 1 article (06/2021)
6.	Zheng, Yulong: 1 article (06/2021)
7.	Fan, Gang: 1 article (02/2021)
8.	Liang, Weiwen: 1 article (02/2021)
9.	Liu, Guangli: 1 article (02/2021)
10.	Tang, Guangmin: 1 article (02/2021)

Related Diseases

1.	Diabetes Complications 09/01/2013 - "Furthermore, methyl-3,5-di-O-caffeoylquinate inhibited galactitol formation in the rat lens and in erythrocytes incubated with a high concentration of glucose, indicating that this compound may be effective in preventing diabetic complications."
2.	Human Influenza (Influenza) 01/01/2012 - "These data indicate that PWE, PEE or 3,4-diCQA possesses a novel and unique mechanism of anti-influenza viral activity, that is, enhancing viral clearance by increasing TRAIL." 10/01/2005 - "The antiviral action of 3,4-di-O-caffeoylquinic acid and 3,5-di-O-caffeoylquinic acid was specific against RSV, as they had no obvious antiviral activity against influenza A (Flu A), Coxsackie B3 (Cox B3), and Herpes simplex type one (HSV-1) viruses. "
3.	Ganglion Cysts (Ganglion) 01/02/2007 - "WEP, 3,4-di-O-caffeoylquinic acid, 3,5-di-O-caffeoylquinic acid, chlorogenic acid, and p-coumaric acid (but not artepillin C, baccharin, or drupanin) concentration-dependently inhibited oxidative stress-induced neurotoxicity [achieved using L-buthionine-(S,R)-sulfoximine (BSO) to deplete glutathione in combination with glutamate to inhibit cystine uptake] in cultured retinal ganglion cells (RGC-5, a rat ganglion cell line transformed using E1A virus). "
4.	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/01/2023 - "Binding free energy calculations demonstrated that 3,4-dicaffeoylquinic acid and Chlorogenic acid exhibited higher binding free energy than the reference agonist, suggesting their potential as candidates for experimental validation in future drug discovery efforts targeting PPARγ for the treatment of T2D and metabolic syndrome."
5.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 11/01/2020 - "A rapid and selective method based on ultra-fast liquid chromatography with tandem mass spectrometry was established and validated to simultaneously quantify chlorogenic acid, 1,3-O-dicaffeoylquinic acid, isochlorogenic acid A, neochlorogenic acid, erigeside I, cryptochlorogenic acid, apigenin-7-O-glucuronide, scutellarin, isochlorogenic acid B, and isochlorogenic acid C of Deng-Zhan-Xi-Xin injection in both sham and middle cerebral artery occlusion rats. "

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Galactitol
3.	Chlorogenic Acid
4.	Acids
5.	3,5-dicaffeoylquinic acid
6.	Glutamic Acid (Glutamate)
7.	scutellarin
8.	5'-O-caffeoylquinic acid
9.	arctiin
10.	arctigenin