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dehydroandrographolide

Also Known As:

2(3H)-Furanone, 3-(2-((1R,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethylidene)-, (3E)-

Networked: 18 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - dehydroandrographolide: 18

Experts

1.	Chen, Mu-Kuan: 3 articles (01/2017 - 10/2015)
2.	Hsieh, Ming-Ju: 3 articles (01/2017 - 10/2015)
3.	Yang, Shun-Fa: 3 articles (01/2017 - 10/2015)
4.	Che, Delu: 2 articles (05/2022 - 01/2019)
5.	Hou, Yajing: 2 articles (05/2022 - 01/2019)
6.	Li, Lihua: 2 articles (01/2019 - 10/2017)
7.	Liu, Xuefeng: 2 articles (01/2019 - 10/2017)
8.	Xie, Jing: 2 articles (01/2019 - 10/2017)
9.	Chiou, Hui-Ling: 2 articles (01/2017 - 10/2015)
10.	Lin, Chiao-Wen: 2 articles (01/2017 - 10/2015)

Related Diseases

1.	Zika Virus Infection 12/05/2022 - "Preliminary SAR reveals that C19-modification with bulky groups is necessary for anti-ZIKV infection and replication, anti-ZIKV activity of 5a comes from itself bearing hindered trityl ether but not from its instability, the backbone of dehydroandrographolide is more effective against ZIKV infection than that of andrographolide, and 3-oxime derivatives are more active against ZIKV infection than 3-alcohol derivatives. "
2.	Neoplasms (Cancer) 08/25/2023 - "Studies have shown that dehydroandrographolide (DA) has been shown to have anti-cancer activity in a variety of cancers, but it has not been reported in GC. " 01/01/2019 - "Dehydroandrographolide (DA) is one of principal components of Andrographis paniculata (Burm.f.) Nees (family: Acanthaceae) and considered the main contributors of its therapeutic properties, such as anti-tumor. "
3.	Mouth Neoplasms (Oral Cancer) 01/01/2017 - "Correction: Dehydroandrographolide, an iNOS inhibitor, extracted from Andrographis paniculata (Burm.f.) Nees, induces autophagy in human oral cancer cells." 10/13/2015 - "Dehydroandrographolide, an iNOS inhibitor, extracted from Andrographis paniculata (Burm.f.) Nees, induces autophagy in human oral cancer cells." 01/01/2017 - "Dehydroandrographolide inhibits oral cancer cell migration and invasion through NF-κB-, AP-1-, and SP-1-modulated matrix metalloproteinase-2 inhibition."
4.	Acute Lung Injury 06/01/2023 - "The effects and mechanisms of the anti-COVID-19 traditional Chinese medicine, Dehydroandrographolide from Andrographis paniculata (Burm.f.) Wall, on acute lung injury by the inhibition of NLRP3-mediated pyroptosis." 09/01/2012 - "Dehydroandrographolide succinate can alleviate oxidative stress in LPS-induced acute lung injury possibly by inactivating iNOS." 09/01/2012 - "[Dehydroandrographolide succinate inhibits oxidative stress in mice with lipopolysaccharide-induced acute lung injury by inactivating iNOS]." 09/01/2012 - "To investigate the effect of dehydroandrographolide succinate (DAS) on oxidative stress and induced nitric oxide synthase (iNOS) expression in a mouse model of lipopolysaccharide (LPS)-induced acute lung injury. "
5.	Respiratory Tract Infections (Respiratory Tract Infection) 04/30/2020 - "Dehydroandrographolide succinate (DAS) injection, which was approved in China for the treatment of viral pneumonia and upper respiratory tract infections, is often off-label used for nebulization therapy to avoid the adverse drug reactions associated with the injection. " 08/15/2010 - "A LC-MS/MS method was developed and validated for the determination of dehydroandrographolide succinate (DAS), a traditional Chinese medicine derivative used for the treatment of pneumonia, upper respiratory tract infection, and chronic bronchitis. "

Related Drugs and Biologics

1.	andrographolide
2.	Ether (Diethyl Ether)
3.	Succinic Acid (Succinate)
4.	amsonic acid (DAS)
5.	Potassium
6.	Matrix Metalloproteinase 2 (Gelatinase A)
7.	Nitric Oxide Synthase (NO Synthase)
8.	Lipopolysaccharides
9.	Immunoglobulin E (IgE)
10.	Antiviral Agents (Antivirals)

Related Therapies and Procedures

1.	Chinese Traditional Medicine (Traditional Chinese Medicine)
2.	Therapeutics