mouse D-JNKI-1

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4 relevant articles (0 outcomes, 2 trials/studies) found for this Bio-Agent

Description: a cell permeable peptide that blocks the MAPK-JNK signal pathway; has potential therapeutic value for long-term protection of both the morphological integrity and physiological function of the organ of Corti during times of oxidative stress

Also Known As:

D-JNKI-1, mouse; AM 111; AM-111; AM111 peptide

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins

Peptides: 16375

mouse D-JNKI-1: 4

Related Diseases

1.	Inflammation 12/01/2007 - "OBJECTIVES/HYPOTHESIS: This study investigated the otoprotective properties of AM-111, an inhibitor of c-Jun N-terminal kinase-mediated apoptosis and inflammation. " Order ALL the reference details at left...
2.	Noise-Induced Hearing Loss (Acoustic Trauma) 09/01/2007 - "SUBJECTS AND METHODS: For the first application of AM-111 in humans, we organized a clinical phase I/II trial in patients with acute acoustic trauma after exposure to firecrackers in Berlin and Munich on New Year's Eve 2005/2006. " Order ALL the reference details at left...
3.	Hearing Loss (Hearing Impairment) 12/01/2007 - "AM-111 reduces hearing loss in a guinea pig model of acute labyrinthitis." 04/01/2007 - "AM-111 protects against permanent hearing loss from impulse noise trauma." Order ALL the reference details at left...
4.	Wounds and Injuries (Trauma) 04/01/2007 - "The otoprotective peptide AM-111, a cell-permeable inhibitor of JNK mediated apoptosis, was tested for its efficacy as a rescue agent following impulse noise trauma. " 04/01/2007 - "AM-111 protects against permanent hearing loss from impulse noise trauma." Order ALL the reference details at left...
5.	Labyrinthitis (Otitis Interna) 12/01/2007 - "AM-111 reduces hearing loss in a guinea pig model of acute labyrinthitis." 12/01/2007 - "CONCLUSION: AM-111 delivered over the round window membrane in a 100 microL hyaluronic acid formulation at a 100 micromol/L concentration immediately after induction of acute labyrinthitis in the guinea pig cochlea protects hearing, reduces hair cell loss, and reduces the number of inflammatory cells at 21 days after treatment." Order ALL the reference details at left...

Related Drugs and Biologics

1.	JNK Mitogen-Activated Protein Kinases
2.	Hyaluronic Acid (Hyaluronan)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)

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