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IC 87114

structure in first source

Also Known As:

IC-87114; IC87114

Networked: 26 relevant articles (4 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Adenine: 2120
        IC 87114: 26
    - Quinazolines: 402
      - IC 87114: 26

Experts

1.	Chang, Ping: 2 articles (06/2021 - 01/2021)
2.	Li, Jiahui: 2 articles (06/2021 - 01/2021)
3.	Tang, Haixiong: 2 articles (06/2021 - 01/2021)
4.	Yao, Lihong: 2 articles (06/2021 - 01/2021)
5.	Chae, Han-Jung: 2 articles (01/2020 - 01/2018)
6.	Kim, Hyung-Ryong: 2 articles (01/2020 - 01/2018)
7.	Lee, Geum-Hwa: 2 articles (01/2020 - 01/2018)
8.	Lee, Hwa-Young: 2 articles (01/2020 - 01/2018)
9.	Lee, Yong-Chul: 2 articles (01/2020 - 01/2018)
10.	Puri, Kamal D: 2 articles (08/2006 - 03/2006)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2020 - "Pre-treatment of immunocompetent mice with the PI3Kδ-selective inhibitor IC87114 or the clinically approved idelalisib (CAL-101), prior to intravenous delivery of a tumor-tropic VV, dramatically improved viral delivery to tumors. " 01/15/2017 - "Herein, we developed hyaluronic acid-modified poly(dl-lactic-co-glycolic acid)-poly (ethylene glycol) nanoparticles (PLGA-PEG-HA NPs) for targeted delivery of TTQ (thio-tetrazolyl analog of a clinical candidate, IC87114) to CD44 overexpressing cancer cells. "
2.	Thyroid Neoplasms (Thyroid Cancer) 01/01/2018 - "These results suggest that application of IC87114 may prove to be a particularly effective treatment for thyroid cancer." 01/01/2018 - "Here, we demonstrated that IC87114 significantly inhibited both the migration and invasion of thyroid cancer cells, which can be mediated by inhibition of PI3K/Akt pathway. " 01/01/2018 - "Little is known about the role of IC87114 in the initiation and progression of thyroid cancer. " 01/01/2018 - "PI3K inhibitors IC87114 inhibits the migration and invasion of thyroid cancer cell in vitro and in vivo."
3.	Proteinuria 06/01/2014 - "We showed that IC87114 improved renal function by decreasing the levels of proteinuria and serum creatinine, ameliorating the pathologic changes of kidneys and IgG and C3 deposition. "
4.	Multiple Sclerosis 01/01/2015 - "We investigated the therapeutic efficacy of a selective PI3Kδ inhibitor IC87114 in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). "
5.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/01/2015 - "We investigated the therapeutic efficacy of a selective PI3Kδ inhibitor IC87114 in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). "

Related Drugs and Biologics

1.	idelalisib
2.	Immunoglobulin G (IgG)
3.	Creatinine
4.	Cytokines
5.	Antigens
6.	Therapeutic Uses
7.	Amphotericin B (Amphotericin)
8.	Roflumilast
9.	1- ((2- ((2- chloropyridin- 4yl)amino)- 4'- (cyclopropylmethyl)- (4,5'- bipyrimidin)- 2'- yl)amino)- 2- methylpropan- 2- ol
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Therapeutics
2.	Inhalation Administration