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2,2'- (3- methoxy- 1'amyl- 5'- methyl- 4- (1- pyrryl)) dipyrryl-methene

A prodigiosin-like immunosuppressant from an alkalophilic Micrococcus sp.; structure in first source

Also Known As:

MAMPDM

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Acyclic Hydrocarbons
    - Alkenes: 265
      - 2,2'-(3-methoxy-1'amyl-5'-methyl-4-(1-pyrryl)) dipyrryl-methene: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - 2,2'-(3-methoxy-1'amyl-5'-methyl-4-(1-pyrryl)) dipyrryl-methene: 2

Experts

1.	Chander, Ramesh: 2 articles (03/2008 - 06/2007)
2.	Deorukhkar, Amit A: 2 articles (03/2008 - 06/2007)
3.	Sainis, Krishna B: 2 articles (03/2008 - 06/2007)
4.	Pandey, Ruchi: 1 article (03/2008)
5.	Ghosh, Sukhendu B: 1 article (06/2007)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2007 - "The red pigment (MAMPDM) of this organism showed selective cytotoxic activity in cancer cell lines of different origin (LS-A and U937) and reduced toxicity to non-malignant cells. " 06/01/2007 - "A bacterial strain producing a novel prodigiosin analogue 2,2'-[3-methoxy-1'amyl-5'-methyl-4-(1''-pyrryl)] dipyrrylmethene (MAMPDM) possessing potent cytotoxic activity towards cancer cells was isolated and identified. "
2.	Necrosis 03/01/2008 - "MAMPDM could induce cell death by either apoptosis or necrosis depending upon the cell type. " 03/01/2008 - "In contrast to induction of necrosis in S-180 cells, MAMPDM induced apoptotic cell death in EL-4 cells as evident by activation of caspase 3, fragmentation of DNA and sub-diploid DNA containing cells. "
3.	Fibrosarcoma 03/01/2008 - "MAMPDM inhibited the proliferation of murine fibrosarcoma, S-180 cells and induced cell death. "

Related Drugs and Biologics

1.	Caspase 3 (Caspase-3)
2.	Prodigiosin
3.	DNA (Deoxyribonucleic Acid)