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4-fluorobenzoyl-TN-14003

has antineoplastic activity; amino acid sequence in first source

Also Known As:

4-fluorobenzoyl-TN14003; 4F-benzoyl-TN14003; BL-8040; T140 compound

Networked: 7 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - 4-fluorobenzoyl-TN-14003: 7

Experts

1.	Peled, Amnon: 4 articles (01/2021 - 03/2011)
2.	Abraham, Michal: 3 articles (01/2021 - 03/2011)
3.	Fujii, Nobutaka: 3 articles (10/2008 - 08/2003)
4.	Tamamura, Hirokazu: 3 articles (10/2008 - 08/2003)
5.	Bohana-Kashtan, Osnat: 2 articles (01/2021 - 01/2020)
6.	Nagler, Arnon: 2 articles (01/2021 - 03/2011)
7.	Pereg, Yaron: 2 articles (01/2021 - 01/2018)
8.	Sorani, Ella: 2 articles (01/2021 - 01/2020)
9.	Beider, Katia: 2 articles (01/2018 - 03/2011)
10.	Eizenberg, Orly: 2 articles (01/2018 - 03/2011)

Related Diseases

1.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/01/2021 - "The current results demonstrate the efficacy of CXCR4 targeting with BL-8040 and support continued clinical development in acute myelogenous leukemia." 01/01/2021 - "BL-8040 CXCR4 antagonist is safe and demonstrates antileukemic activity in combination with cytarabine for the treatment of relapsed/refractory acute myelogenous leukemia: An open-label safety and efficacy phase 2a study."
2.	Pancreatic Neoplasms (Pancreatic Cancer) 01/01/2020 - "BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the COMBAT trial."
3.	Neoplasms (Cancer) 01/01/2020 - "BL-8040 increased CD8+ effector T cell tumor infiltration, decreased myeloid-derived suppressor cells (MDSCs) and further decreased circulating regulatory T cells. " 01/01/2018 - "Moreover, CXCR4 inhibition with the high-affinity CXCR4 antagonist BL-8040 prevented tumor growth and reduced survival of tumor cells. " 03/01/2011 - "CXCR4 antagonist 4F-benzoyl-TN14003 inhibits leukemia and multiple myeloma tumor growth."
4.	Neoplasm Metastasis (Metastasis) 10/01/2008 - "Slow release administration of 4F-benzoyl-TN14003, for example, was found to significantly reduce pulmonary metastasis of breast cancer cells in severe combined immunodeficient mice. " 08/28/2003 - "Furthermore, slow release administration by subcutaneous injection using an Alzet osmotic pump of a potent and bio-stable T140 analog, 4F-benzoyl-TN14003, gave a partial, but statistically significant (P</=0.05 (t-test)) reduction in pulmonary metastasis of MDA-MB-231 in SCID mice, even though no attempt was made to inhibit other important targets such as CCR7. "
5.	Multiple Myeloma 03/01/2011 - "CXCR4 antagonist 4F-benzoyl-TN14003 inhibits leukemia and multiple myeloma tumor growth."

Related Drugs and Biologics

1.	Cytarabine (Cytosar-U)
2.	pembrolizumab
3.	T140 peptide

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Subcutaneous Injections