2,2',4,4',5-brominated diphenyl ether

06/01/2013 - "When comparing infected mice exposed to the two BDE-99 doses, the higher BDE dose resulted in increased virus amounts in the liver, and decreased infection-induced expression of MCP-1. "
06/01/2013 - "In mice the common human coxsackievirus B3 (CVB3) infection has been shown to change the tissue distribution of BDE-99. "
12/05/2007 - "In the present study, CVB3 adapted to Balb/c mice was used to study the combined effects of infection and exposure to pure BDE-99 or the commercial mixture Bromkal on CYP1A1 and CYP2B expression in the lungs and pancreas on day 3 of the infection. "
06/01/2013 - "Moreover, the fact that CVB3 infection increased the BDE-99 levels in liver but not in serum may impair the risk assessment of polybrominated diphenyl ethers (PBDEs) in subclinical and clinically infected individuals, as serum levels is the common marker of exposure."
06/01/2013 - "We now investigate how CVB3 infection in mice affects liver uptake of (14)C at two doses of radiolabelled BDE-99, and whether increased tissue levels are related to changed virus replication and gene expression of the proinflammatory chemokine monocyte chemoattractant protein-1 (MCP-1). "

03/01/2015 - "This study provides new insight into the tumorigenesis and metastasis of CRC stimulated by BDE-99 and possibly other PBDE congeners."

03/01/2015 - "The objective of the present study was to investigate the effects of BDE-99 on colorectal cancer (CRC) cells. "
03/01/2015 - "BDE-99 (2,2',4,4',5-pentabromodiphenyl ether) triggers epithelial-mesenchymal transition in colorectal cancer cells via PI3K/Akt/Snail signaling pathway."

03/01/2015 - "This study provides new insight into the tumorigenesis and metastasis of CRC stimulated by BDE-99 and possibly other PBDE congeners."

04/30/2010 - "Adult male rats (10 per group) received BDE-99 by gavage at a single dose of 0, 0.6, and 1.2mg/kg body weight. "
04/15/2010 - "Adult male rats (10/group) received BDE-99 by gavage at single doses of 0, 0.6 or 1.2mg/kg/body weight. "
07/15/2004 - "Higher tissue concentrations of BDE-99 were found in suckling neonates than in dams, probably due to a high dose per kilogram body weight from milk and an efficient absorption via the gastrointestinal tract in the pups."
04/30/2010 - "In kidney, CAT activity was significantly decreased, while GSSG/GSH ratio significantly increased following BDE-99 exposure at 1.2mg/kg body weight. "
08/15/2007 - "Tadpoles exposed to BDE-99 also showed lower developmental stage but no effects on body weight or body length, suggesting possible thyroid hormone disruption. "