COP9 Signalosome Complex

A multiprotein complex that functions as a peptide hydrolase, or isopeptidase to cleave NEDD8 PROTEIN from the CULLIN and UBIQUITIN-PROTEIN LIGASES, controlling the activity of the ligases. It is highly conserved in eukaryotes and typically consists of 8 subunits (CSN 1-8 proteins). The COP9 signalosome was originally identified in plants, where it controls gene transcription in response to light.

Also Known As:

COP9 Signalosome (CSN); COP9 Signalosome Subunit 1; COP9 Signalosome Subunit 2; COP9 Signalosome Subunit 3; COP9 Signalosome Subunit 4; COP9 Signalosome Subunit 5; COP9 Signalosome Subunit 6; COP9 Signalosome Subunit 7A; COP9 Signalosome Subunit 7B; COP9 Signalosome Subunit 8; COP9 Signalsome; Constitutive Photomorphogenesis 9 Signalosome; Constitutive Photomorphogenesis 9 Signalsome; FUSCA Protein 11; G Protein Pathway Suppressor 1; Sgn3; Signalosome Subunit 3; Signalosome Complex, COP9; Signalsome, COP9; Subunit 3, Signalosome

Macromolecular Substances: 97
- Multiprotein Complexes: 125
  - COP9 Signalosome Complex: 54
Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Endopeptidases: 633
        Ubiquitin-Specific Proteases: 864
        COP9 Signalosome Complex: 54
  - Deubiquitinating Enzymes: 1337
    - Ubiquitin-Specific Proteases: 864
      - COP9 Signalosome Complex: 54

human COPS3 protein

Bio-Agent Context: Research Results