Erianin

from Dendrobium chrysotoxum; structure in first source

Also Known As:

2-methoxy-5-(2-(3,4,5-trimethoxyphenyl)-ethyl)-phenol; 2-methoxy-5-(2-(3,4,5-trimethoxyphenyl)ethyl)phenol; 3-hydro-4,3',4',5'-quamythloxy-stilbene; Eri cpd; dihydrocombretastatin A-4(1c); isoerianin

Networked: 54 relevant articles (2 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Phenol: 2172
        Erianin: 54
        Benzyl Compounds: 2
        Bibenzyls: 16
        Erianin: 54

Experts

1.	Xie, Tian: 4 articles (01/2022 - 01/2020)
2.	Cao, Yiou: 3 articles (01/2022 - 04/2017)
3.	Duan, Ting: 3 articles (01/2022 - 01/2020)
4.	Feng, Jiao: 3 articles (01/2022 - 01/2020)
5.	Liu, Jianwen: 3 articles (01/2022 - 04/2017)
6.	Sui, Xinbing: 3 articles (01/2022 - 01/2020)
7.	Yan, Lili: 3 articles (01/2022 - 01/2020)
8.	Li, Wenhua: 2 articles (01/2022 - 01/2019)
9.	Liu, Jiajun: 2 articles (01/2022 - 12/2021)
10.	Liu, Xin: 2 articles (01/2022 - 01/2021)

Related Diseases

1.	Uterine Cervical Neoplasms (Cancer of the Cervix) 06/12/2021 - "We detected the anti-tumour activity of erianin using in vitro HeLa cell models and in vivo cervical cancer xenograft models. " 06/12/2021 - "Collectively, these results revealed previously unknown properties of erianin and provided a new basis for improving the efficacy of immunotherapy against cervical cancer and other malignant tumours through PD-L1." 10/01/2018 - "Thus, erianin has the promise to be developed further for cervical cancer therapy." 10/01/2018 - "Erianin inhibits human cervical cancer cell through regulation of tumor protein p53 via the extracellular signal-regulated kinase signaling pathway." 01/01/2023 - "ERIANIN has broad-spectrum antitumor effects, and its tumor-suppressive effects have been confirmed in the study of various diseases, such as precancerous lesions of the stomach, gastric cancer, liver cancer, lung cancer, prostate cancer, bladder cancer, breast cancer, cervical cancer, osteosarcoma, colorectal cancer, leukaemia, nasopharyngeal cancer and melanoma through the multiple signaling pathways. "
2.	Colonic Neoplasms (Colon Cancer) 12/01/2021 - "Our research showed that erianin could significantly inhibit the proliferation of human colon cancer oxaliplatin-resistant cells, and suppress the cell cycle of oxaliplatin-resistant cells in the G2/M phase, indicating that erianin could regulate the MDR phenotype of oxaliplatin-resistant cells, and its mechanism might be the inhibition of STAT3 signaling pathway and the significant reduction of P-gp expression. " 12/01/2021 - "In this study, human colon cancer oxaliplatin-resistant cells were treated with oxaliplatin combined with the natural product erianin. " 12/01/2021 - "The effect and mechanism of erianin on the reversal of oxaliplatin resistance in human colon cancer cells." 12/01/2021 - "However, this study provides a theoretical basis for the clinical application of erianin in platinum-based chemotherapy for colon cancer."
3.	Neoplasms (Cancer) 12/05/2023 - "In recent years, although important progress in the development of Erianin and the publication of some reviews in this aspect, the mechanism against various cancers, pharmacokinetic study, structural modification as well as structure-activity relationships have not been thoroughly considered. " 01/01/2023 - "Also, our study demonstrated for the first time the relationship between erianin and mi-RNAs in a cancer cell. " 01/01/2022 - "Overall, in this study, we aimed at 1) collecting all experiment-based important information regarding the anticancer effect and pharmacological mechanism of erianin, 2) providing the predicted therapeutic targets and signaling pathways that erianin might act on in cancers, and 3) especially providing in silico ADMET properties of erianin." 04/01/2017 - "The antitumor activity of erianin in many kinds of cancers had been demonstrated in previous studies. " 05/20/2023 - "The previous research has focused on the suppressive effects of Erianin on tumor progression, but its impact on cancer stemness has not been reported. "
4.	Lung Neoplasms (Lung Cancer) 05/20/2023 - "Taken together, this study reveals that Erianin has the potential to suppress lung cancer stemness and could be a valuable chemotherapeutic enhancer for lung cancer." 05/20/2023 - "This study aimed to investigate the effects of Erianin on lung cancer stemness. " 08/01/2021 - "In this study, we assessed the effect of erianin on lung cancer in terms of cell growth inhibition and the related mechanism. " 05/20/2023 - "Furthermore, Erianin was shown to enhance chemosensitivity of lung cancer cells. " 05/20/2023 - "Subsequently, we found that Erianin significantly attenuated lung cancer stemness through various analyses, including qRT-PCR, western blot, sphere-formation, and ALDH activity detection. "
5.	Urinary Bladder Neoplasms (Bladder Cancer) 01/01/2021 - "In this study, we found that erianin triggered cell death and cell cycle arrest in bladder cancer cells. " 01/01/2019 - "In this study, we assessed the effects of Erianin on bladder cancer growth and elucidated the related mechanisms. " 01/01/2021 - "In conclusion, our data provide the first evidence that erianin can initiate ferroptosis-like cell death and lipid peroxidation in bladder cancer, which will hopefully become a promising anticancer compound for the treatment of bladder cancer." 01/01/2021 - "However, the effects and molecular mechanisms of erianin in bladder cancer cells remain unexplored. " 01/01/2021 - "Natural Product Erianin Inhibits Bladder Cancer Cell Growth by Inducing Ferroptosis via NRF2 Inactivation."

Related Drugs and Biologics

1.	Oxaliplatin (Eloxatin)
2.	Antioxidants
3.	Proteins (Proteins, Gene)
4.	Antineoplastic Agents (Antineoplastics)
5.	Therapeutic Uses
6.	Pyruvate Carboxylase
7.	Reactive Oxygen Species (Oxygen Radicals)
8.	Sodium
9.	Messenger RNA (mRNA)
10.	Platinum

Related Therapies and Procedures

1.	Immunotherapy
2.	Drug Therapy (Chemotherapy)
3.	Therapeutics
4.	Chinese Traditional Medicine (Traditional Chinese Medicine)
5.	Castration