cribrostatin 6
antineoplastic agent from Cribrochalina species; structure in first source
Networked: 4
relevant articles (0 outcomes,
0 trials/studies)
Bio-Agent Context: Research Results
Experts
1. | Asby, D J:
1 article
(10/2016)
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2. | Bienemann, A S:
1 article
(10/2016)
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3. | Chai, C L L:
1 article
(10/2016)
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4. | Chen, A:
1 article
(10/2016)
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5. | Cuda, F:
1 article
(10/2016)
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6. | Harrowven, D C:
1 article
(10/2016)
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7. | Light, M E:
1 article
(10/2016)
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8. | Radigois, M G:
1 article
(10/2016)
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9. | Tavassoli, A:
1 article
(10/2016)
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10. | Wilson, D C:
1 article
(10/2016)
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Related Diseases
1. | Neoplasms (Cancer)
10/04/2016
- " Several small molecules, including the marine natural product cribrostatin 6, have been demonstrated to trigger apoptosis in cancer cells by increasing intracellular ROS. " 10/04/2016
- " Triggering apoptosis in cancer cells with an analogue of cribrostatin 6 that elevates intracellular ROS." 04/01/2003
- " Cribrostatin 6, a dark blue cancer cell growth inhibiting (P388 ED(50) 0.3 microg/mL) constituent of the Republic of Maldives marine sponge Cribrochalina sp., has been assigned structure 3 on the basis of a combination of HRMS, high-field (500 MHz, HMBC, and GOESY experiments) (15)N, (1)H, and (13)C NMR, and X-ray crystal structure analyses. " 10/04/2016
- " We establish that placing a phenyl ring on carbon 8 of cribrostatin 6 leads to increased potency, and observe a window of selectivity towards cancer cells. " 12/02/2011
- " New insights into cyclobutenone rearrangements: a total synthesis of the natural ROS-generating anti-cancer agent cribrostatin 6."
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