ME3738

08/01/2003 - "Therefore, we demonstrate that ME3738 triggers IL-6 expression, which activates pathways that are relevant to protect from Con A-induced liver failure."
08/01/2003 - "In addition, ME3738 did not protect IL-6(-/-) animals from Con A-induced liver failure, while IL-6 injection was still effective. "
08/01/2003 - "ME3738 protects from concanavalin A-induced liver failure via an IL-6-dependent mechanism."
01/01/2007 - "It has been demonstrated that ME3738 is stimulate to produce IL-6 and that it protects against concanavalin A-induced liver failure. "
07/17/2006 - "Protective effects of alpha1-acid glycoprotein and serum amyloid A on concanavalin A-induced liver failure via interleukin-6 induction by ME3738."

12/01/2016 - "The effect of ME3738 on hepatocellular carcinoma (HCC) cell lines was investigated in the present study. "
12/01/2016 - "Antiproliferative effect of ME3738, a derivative of soyasapogenol, on hepatocellular carcinoma cell lines in vitro and in vivo."

07/01/2008 - "Hepatic Hyp content and the area of hepatic fibrosis in BDL rats treated with ME3738 were reduced by 24% and 39% compared with non-treated BDL rats (hepatic Hyp, 9.40 +/- 2.85 vs. 12.39 +/- 3.91 mg/liver; P = 0.036; area of hepatic fibrosis, 13.1 +/- 3.8 vs. 21.5 +/- 10.9; P = 0.045). "
07/01/2008 - "The aim of this study was to examine the preventive effects of ME3738 on hepatic fibrosis induced by bile duct ligation (BDL) in rats. "
07/01/2008 - "Preventive effects of ME3738 on hepatic fibrosis induced by bile duct ligation in rats."
07/01/2008 - "Oral ME3738 administration may prevent the progression of hepatic fibrosis in BDL rats through suppression of the activation and collagen synthesis of HSC and, in part, oxidative stress. "

01/01/2007 - "In the present study, we investigated whether ME3738 prevents fatty liver in ethanol-fed rats. "
01/01/2007 - "Oral administration of ME3738, inducer of IL-6 may prevent the development of fatty liver caused by chronic ethanol consumption."

11/28/2007 - "ME3738 (22beta-methoxyolean-12-ene-3beta, 24(4beta)-diol), a derivative of soyasapogenol, attenuates liver disease in several models of chronic liver inflammation. "
08/01/2003 - "ME3738 is a new compound that attenuates liver disease in several models of acute and chronic liver inflammation. "
07/01/2011 - "ME3738 (22β-methoxyolean-12-ene-3β, 24-diol), a derivative of soyasapogenol B, attenuates liver disease in several animal models of acute and chronic liver injury. "