locked nucleic acid

oligonucleotide that contains one or more LNA monomer (2'-O,4'-C-methylene-beta-D-ribofuranosyl monomer); has an exceptionally high affinity and specificity toward their complementary DNA and RNA target molecules, used in functional genomics applications; structure in first source

Also Known As:

Networked: 253 relevant articles (20 outcomes, 37 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kauppinen, Sakari: 9 articles (01/2022 - 02/2006)
2.	Sharifi, Mohammadreza: 9 articles (08/2019 - 01/2014)
3.	Tassone, Pierfrancesco: 5 articles (01/2021 - 01/2014)
4.	Sharifi, M: 5 articles (01/2020 - 01/2016)
5.	Kanwar, Jagat R: 5 articles (07/2017 - 06/2012)
6.	Obad, Susanna: 5 articles (10/2016 - 08/2012)
7.	Di Martino, Maria Teresa: 4 articles (06/2020 - 01/2014)
8.	Tagliaferri, Pierosandro: 4 articles (06/2020 - 01/2014)
9.	Salehi, R: 4 articles (01/2020 - 01/2016)
10.	Henshall, David C: 4 articles (01/2018 - 09/2013)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2005 - "Both alpha-L-LNA and LNA gapmer ODNs had a high efficacy of tumor-growth inhibition and were nontoxic at the tested dosages. " 01/01/2008 - "Locked nucleic acid holds promise in the treatment of cancer." 01/01/2023 - "Safety and activity of the first-in-class locked nucleic acid (LNA) miR-221 selective inhibitor in refractory advanced cancer patients: a first-in-human, phase 1, open-label, dose-escalation study." 01/01/2023 - "Locked nucleic acid (LNA): A modern approach to cancer diagnosis and treatment." 01/01/2022 - "EGFR mutations were detected in 68 tumor tissue samples and 179 plasma samples using Anlongen Locked Nucleic Acid-Amplification Refractory Mutation System (LNA-ARMS) EGFR Mutation Detection Kit. "
2.	Neoplasm Metastasis (Metastasis) 01/01/2022 - "In preclinical brain metastasis murine models, locked nucleic acid-BMOR, a designed silencer targeting BMOR, is effective in suppressing the metastatic colonization of cancer cells in the brain for brain metastasis. " 07/01/2016 - "miR-21 expression was investigated by using locked nucleic acid- fluorescence in situ hybridization in the center and periphery of the primary cancer and in distant metastasis from 170 patients with advanced CRC. " 04/01/2014 - "Silencing of miR-133a with locked nucleic acid (LNA) reduced cell invasion of this cell population, and systemic administration of LNA along with chemotherapy suppressed lung metastasis and prolonged the survival of osteosarcoma-bearing mice. " 06/01/2010 - "This conference report highlights selected presentations on the development of the third-generation camptothecin analog TH-1320 (Threshold Pharmaceuticals Inc), the silencing of the androgen receptor in prostate cancer by the novel locked nucleic acid-based antisense oligonucleotide EZN-4176 (Enzon Pharmaceuticals Inc/Santaris Pharma A/S), the inhibition of PC-3 cell invasiveness and metastasis by the CXCR4 antagonist CTCE-9908 (British Canadian BioSciences Corp), the antitumor efficacy of the CDH3 mAb PPMX-2017 (Perseus Proteomics Inc), and an anti-IL-6 mAb (MedImmune LLC) that suppresses tumor growth in vivo."
3.	Infections 11/01/2013 - "Two fluorescent, locked nucleic acid probes ShaemLNA5 and SmanLNA2, of 20-26bp in length, were identified and found to be effective in providing evidence of infection in field-collected snails. " 01/01/2016 - "The aim of this study was to provide a direct fluorescence in situ hybridization (FISH) method based on locked nucleic acid (LNA) probes, which targets the phage replication phase, allowing the study of population dynamics during infection. " 03/21/2023 - "Locked nucleic acid real-time polymerase chain reaction method identifying two polymorphisms of hepatitis B virus genotype C2 infections, rt269L and rt269I." 06/01/2014 - "Our findings showed that bmnpv-miR-3 expresses during early stage of infection, and negatively regulates the expression of P6.9. There was an upregulation in P6.9 expression upon blocking of bmnpv-miR-3 by Locked Nucleic Acid (LNA), whereas overexpression of bmnpv-miR-3 resulted in a decreased expression of P6.9. Besides, a remarkable enhancement and reduction in the viral loads were observed upon blocking and overexpression of bmnpv-miR-3, respectively. " 03/22/2011 - "Recently, it was demonstrated that locked nucleic acid SPC3649-induced miR-122 antagonism suppressed HCV genotype 1a and 1b infection in vivo. "
4.	Breast Neoplasms (Breast Cancer) 12/07/2014 - "Locked nucleic acid (LNA) is applied in toehold-mediated strand displacement reaction (TMSDR) to develop a junction-probe electrochemiluminescence (ECL) biosensor for single-nucleotide polymorphism (SNP) detection in the BRCA1 gene related to breast cancer. " 01/01/2018 - "In this study, we exploited the exosomes isolated from bone marrow-derived mesenchymal stem cells (MSCs-Exo) to deliver LNA (locked nucleic acid)-modified anti-miR-142-3p oligonucleotides to suppress the expression level of miR-142-3p and miR-150 in 4T1 and TUBO breast cancer cell lines. " 02/01/2017 - "In the present study, blockage of miR-182-5p was performed in human breast cancer cell line (MCF-7) using locked nucleic acid (LNA)-anti-miR. " 01/01/2016 - "Direct detection of circulating free DNA extracted from serum samples of breast cancer using locked nucleic acid molecular beacon." 12/01/2010 - "The future application of locked-nucleic acid miRNA inhibitors, and synergistic approaches involving conventional breast cancer therapeutics opens up promising new perspectives in breast cancer therapy."
5.	Reperfusion Injury 01/01/2016 - "A locked nucleic acid-modified anti-miR-146a given before LPS treatment knocked down miR-146a expression and completely negated LPS-mediated protection against kidney ischemia/reperfusion injury. " 12/01/2012 - "A locked nucleic acid-modified anti-miR-21 given at the time of ischemic preconditioning knocked down miR-21 and significantly exacerbated subsequent ischemia-reperfusion injury in the mouse kidney. " 09/01/2013 - "A locked nucleic acid-modified anti-miR-21, given before xenon preconditioning, knocked down miR-21 effectively, and exacerbated subsequent renal ischemia-reperfusion injury. " 01/01/2012 - "In this study, miR-1 transgenic (miR-1 Tg) mice and locked nucleic acid modified oligonucleotide against miR-1 (LNA-antimiR-1) were used to explore the effects of miR-1 on cardiac ischemia/reperfusion injury (30 min ischemia followed by 24 h reperfusion). "

Related Drugs and Biologics

1.	Antisense Oligonucleotides
2.	Antagomirs
3.	Small Interfering RNA (siRNA)
4.	DNA (Deoxyribonucleic Acid)
5.	Messenger RNA (mRNA)
6.	Nucleotide Aptamers
7.	Androgen Receptors (Androgen Receptor)
8.	5'-ACCaagtttcttcAGC-3'
9.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
10.	Peptides (Polypeptides)

Related Therapies and Procedures

1.	Therapeutics
2.	Injections
3.	Castration
4.	Immunotherapy
5.	Drug Therapy (Chemotherapy)