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transporter associated with antigen processing (TAP)

Also Known As:
ABC transporter TAP; TAP transporter
Networked: 65 relevant articles (0 outcomes, 9 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Ferrone, Soldano: 5 articles (06/2012 - 05/2003)
2. Mathis, J Michael: 3 articles (11/2009 - 01/2008)
3. Zhang, Qian-Jin: 3 articles (11/2009 - 01/2008)
4. Li, Xiao-Lin: 3 articles (11/2009 - 01/2008)
5. Knight, David: 3 articles (11/2009 - 01/2008)
6. Glass, Jonathan: 3 articles (11/2009 - 01/2008)
7. Wang, Xinhui: 2 articles (06/2012 - 07/2005)
8. Jordanova, Ekaterina S: 2 articles (06/2011 - 06/2007)
9. Seliger, Barbara: 2 articles (10/2010 - 05/2003)
10. Odaka, Yoshinobu: 2 articles (11/2009 - 01/2009)

Related Diseases

1. Melanoma (Melanoma, Malignant)
02/01/1996 - "This study was designed to determine whether the adjacent upstream transporter associated with antigen processing (TAP) locus, TAP2, constitutes the centromeric boundary of disease susceptibility in melanoma. "
12/15/2001 - "Sequence analyses of the transporter associated with antigen processing (TAP) in tumor cell lines with deficient MHC class I surface expression identified a bp deletion at position 1489 near the ATP-binding domain of Tap1, causing a frameshift in one melanoma cell line. "
08/01/1998 - "Many melanoma epitopes are presented to cytotoxic T-lymphocytes (CTLs) by major histocompatibility complex (MHC) class I molecules, and it is reasonable to expect that the epitopes would be good substrates for the transporter associated with antigen processing (TAP), as TAP plays a major role in the transport of peptides into the endoplasmic reticulum (ER) for binding to MHC class I molecules. "
05/01/1999 - "In the present study, we HLA-genotyped and identified at a biochemical level the three (HLA-A25, -B8, -Cw7) class I alleles expressed by the previously described [D'Urso CM et al (1992) J Clin Invest 87: 284-292] beta2m-defective human melanoma FO-1 cell line and tested their ability to interact with calnexin, calreticulin and the TAP (transporter associated with antigen processing) complex. "
10/01/1996 - "To gain insight into how tumor antigens are generated and presented, a panel of peptides corresponding to melanoma-specific T cell epitopes were tested for their transport capacity by the transporter associated with antigen processing (TAP). "
2. Infection
3. Human Influenza (Influenza)
4. Hepatocellular Carcinoma (Hepatoma)
5. Rheumatoid Arthritis

Related Drugs and Biologics

1. I-antigen
2. Peptides
3. tapasin
4. Proteasome Endopeptidase Complex (Proteasome)
5. Calnexin
6. HLA-A*0201 antigen
7. Calreticulin
8. Virosomes
9. Interferon-alpha (Interferon Alfa)
10. Ursodeoxycholic Acid (Urso)