QSulf1

an extracellular sulfatase which is a candidate developmental regulator of heparan sulfate proteoglycan sulfation in embryonic progenitor lineages. It has an enzymatic domain which functions in the lysosomal degradation of heparan sulfate. It is a heparan sulfate-specific 6-0 endosulfatase with a high degree of substrate specificity for 6-O-sulfated disaccharides of HS chains of HSPG.

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Sulfatases: 574
        QSulf1: 1

Experts

1.	Ai, Xingbin: 1 article (04/2004)
2.	Emerson, Charles P: 1 article (04/2004)
3.	Freeman, Stephen D: 1 article (04/2004)
4.	Kessler, Daniel S: 1 article (04/2004)
5.	Lu, Qun: 1 article (04/2004)
6.	Pownall, Mary E: 1 article (04/2004)
7.	Wang, Shouwen: 1 article (04/2004)

Related Diseases

1.	Neoplasms (Cancer) 04/06/2004 - "Therefore, QSulf1 provides another reagent to produce enzymatically modified heparin compounds, in vivo and in vitro, to modulate cellular signaling in stem cell-based therapies to promote tissue regeneration and in cancer therapies to control cell growth and block angiogenesis."

Related Drugs and Biologics

1.	Indicators and Reagents (Reagents)
2.	Heparin (Liquaemin)

Related Therapies and Procedures

1.	Therapeutics