|1.||Guan, Lixia: 1 article (01/2011)|
|2.||Zhu, Chenchen: 1 article (01/2011)|
|3.||Lu, Li: 1 article (01/2011)|
|4.||Li, Xiaofen: 1 article (01/2011)|
|5.||Li, Shujue: 1 article (01/2011)|
|6.||Liu, Ningning: 1 article (01/2011)|
|7.||Zhang, Change: 1 article (01/2011)|
|8.||Zhao, Canguo: 1 article (01/2011)|
|9.||Zhao, Kai: 1 article (01/2011)|
|10.||Liu, Jinbao: 1 article (01/2011)|
01/01/2011 - "We report for the first time that Sanggenon C, a natural prenylated flavonoid, inhibits tumor cellular proteasomal activity and cell viability. "
01/01/2011 - "We conclude that Sanggenon C inhibits tumor cell viability via induction of cell cycle arrest and cell death, which is associated with its ability to inhibit the proteasome function and that proteasome inhibition by Sanggenon C at least partially contributes to the observed tumor cell growth-inhibitory activity."
01/01/2011 - "Sanggenon C decreases tumor cell viability associated with proteasome inhibition."
01/01/2011 - "We found that (1) Sanggenon C inhibited tumor cell viability and induced cell cycle arrest at G0/G1 phase; (2) Sanggenon C inhibited the chymotrypsin-like activity of purified human 20S proteasome and 26S proteasome in H22 cell lysate, and Sanggenon C was able to dose-dependently accumulate ubiquitinated proteins and proteasome substrate protein p27; (3) Sanggenon C-induced proteasome inhibition occurred prior to cell death in murine H22 and P388 cell lines; (4) Sanggenon C induced death of human K562 cancer cells and primary cells isolated from leukemic patients. "
|2.||Proteasome Endopeptidase Complex (Proteasome)
|4.||ATP dependent 26S protease (26S proteasome)