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hemoglobin Lepore-Hollandia

cross over between amino acid 22 of delta chain and amino acid 50 of beta chain - (delta 1-22/beta 50-146)

Also Known As:

Hb Lepore-Hollandia

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Hemoglobins: 37188
      - Abnormal Hemoglobins: 120
        hemoglobin Lepore-Hollandia: 5
  - Hemeproteins: 194
    - Globins: 2716
      - Hemoglobins: 37188
        Abnormal Hemoglobins: 120
        hemoglobin Lepore-Hollandia: 5

Experts

1.	Chaibunruang, Attawut: 3 articles (01/2018 - 03/2010)
2.	Fucharoen, Goonnapa: 3 articles (01/2018 - 03/2010)
3.	Fucharoen, Supan: 3 articles (01/2018 - 03/2010)
4.	Srivorakun, Hataichanok: 2 articles (01/2018 - 03/2010)
5.	Singha, Kritsada: 1 article (01/2018)
6.	Bansal, Deepak: 1 article (01/2015)
7.	Chhabra, Sanjeev: 1 article (01/2015)
8.	Das, Reena: 1 article (01/2015)
9.	Hira, Jasbir Kaur: 1 article (01/2015)
10.	Sharma, Prashant: 1 article (01/2015)

Related Diseases

1.	Thalassemia 01/01/2015 - "β-Thalassemia Intermedia Caused by Compound Heterozygosity for Hb Lepore-Hollandia and β-Thalassemia is Rare in the Indian Population." 04/01/2012 - "Using a combination of HPLC and DNA analysis, we have identified eight individuals with Hb Lepore Hollandia from three families including seven heterozygotes and one compound heterozygote with β thalassemia who presented with a severe clinical phenotype. " 11/01/2011 - "Globin gene analyses demonstrated that she carried the Hb Lepore-Hollandia mutation in trans to the Hb E and a compound heterozygosity for α(0)-thalassemia (SEA deletion) and α(+)-thalassemia (3.7 kb deletion), leading to the Hb Lepore EF Bart's disease. " 03/15/2010 - "Using a combination of Hb-HPLC, Hb-capillary electrophoresis and DNA analyses, we have identified 14 patients with Hb Lepore-Hollandia including eight heterozygotes, two double heterozygotes with alpha(+)-thalassemia, two compound heterozygotes with Hb E (initially diagnosed as Hb E-beta-thalassemia) and two previously undescribed conditions of double heterozygote for Hb Lepore/Hb Constant Spring and Hb Lepore/alpha(0)-thalassemia, both associated with higher levels of Hb F and lower levels of Hb Lepore. "
2.	beta-Thalassemia (Cooley's Anemia) 01/01/2015 - "β-Thalassemia Intermedia Caused by Compound Heterozygosity for Hb Lepore-Hollandia and β-Thalassemia is Rare in the Indian Population." 03/15/2010 - "Using a combination of Hb-HPLC, Hb-capillary electrophoresis and DNA analyses, we have identified 14 patients with Hb Lepore-Hollandia including eight heterozygotes, two double heterozygotes with alpha(+)-thalassemia, two compound heterozygotes with Hb E (initially diagnosed as Hb E-beta-thalassemia) and two previously undescribed conditions of double heterozygote for Hb Lepore/Hb Constant Spring and Hb Lepore/alpha(0)-thalassemia, both associated with higher levels of Hb F and lower levels of Hb Lepore. "
3.	alpha-Thalassemia 03/15/2010 - "Using a combination of Hb-HPLC, Hb-capillary electrophoresis and DNA analyses, we have identified 14 patients with Hb Lepore-Hollandia including eight heterozygotes, two double heterozygotes with alpha(+)-thalassemia, two compound heterozygotes with Hb E (initially diagnosed as Hb E-beta-thalassemia) and two previously undescribed conditions of double heterozygote for Hb Lepore/Hb Constant Spring and Hb Lepore/alpha(0)-thalassemia, both associated with higher levels of Hb F and lower levels of Hb Lepore. "
4.	Hemoglobinopathies 01/01/2018 - "Among 5643 subjects referred for hemoglobinopathy investigation during January 2015 to September 2017, 183 (3.2%) were found to carry several Hb variants, including β chain variants (n = 135, 2.4%), α chain variants (n = 33, 0.6%), Hb Lepore-Hollandia (NG_000007.3: g.63290_70702del) and Hb Lepore-Boston-Washington (NG_000007.3: g.63632_71046del) (δβ hybrid Hb) (n = 12, 0.2%) and δ chain variants (n = 3, 0.05%). "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	hemoglobin Lepore
3.	Globins
4.	hemoglobin Lepore Boston-Washington
5.	Hemoglobin Constant Spring