Receptor Tyrosine Kinase-like Orphan Receptors

A family of cell surface receptors that were originally identified by their structural homology to neurotropic TYROSINE KINASES and referred to as orphan receptors because the associated ligand and signaling pathways were unknown. Evidence for the functionality of these proteins has been established by experiments showing that disruption of the orphan receptor genes results in developmental defects.

Also Known As:

NTRKR Receptors; Neurotrophic Tyrosine Kinase, Receptor-related Proteins; ROR Tyrosine Kinase Receptors; ROR1 Tyrosine Kinase; ROR2 Tyrosine Kinase; Receptor Tyrosine Kinase-like Orphan Receptor 1; Receptor Tyrosine Kinase-like Orphan Receptor 2; Kinase, ROR2 Tyrosine; Neurotrophic Tyrosine Kinase, Receptor related Proteins; Receptor Tyrosine Kinase like Orphan Receptor; Receptor Tyrosine Kinase like Orphan Receptor 1; Receptor Tyrosine Kinase like Orphan Receptor 2; Receptor Tyrosine Kinase like Orphan Receptors; Tyrosine Kinase, ROR1; Receptor Tyrosine Kinase-like Orphan Receptor

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        Protein-Tyrosine Kinases: 7697
        Receptor Protein-Tyrosine Kinases: 5999
        Receptor Tyrosine Kinase-like Orphan Receptors: 115
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Receptor Protein-Tyrosine Kinases: 5999
        Receptor Tyrosine Kinase-like Orphan Receptors: 115
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein-Tyrosine Kinases: 7697
      - Receptor Protein-Tyrosine Kinases: 5999
        Receptor Tyrosine Kinase-like Orphan Receptors: 115

mouse Ror1 protein

Bio-Agent Context: Research Results