DNA-(Apurinic or Apyrimidinic Site) Lyase

A DNA repair enzyme that catalyses the excision of ribose residues at apurinic and apyrimidinic DNA sites that can result from the action of DNA GLYCOSYLASES. The enzyme catalyzes a beta-elimination reaction in which the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. This enzyme was previously listed under EC 3.1.25.2.

Also Known As:

AP Endonuclease; AP Lyase; Apurine-Apyrimidine Endonuclease; Apurinic Endonuclease; Apurine Apyrimidine Endonuclease; DNA Endonuclease, Apurinic; Endonuclease, AP; Endonuclease, Apurine-Apyrimidine; Endonuclease, Apurinic; Endonuclease, Apurinic DNA; Apurinic DNA Endonuclease; DNA Lyase (Apurinic or Apyrimidinic); Endodeoxyribonuclease (Apurinic or Apyrimidinic)

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Lyases: 637
    - Carbon-Oxygen Lyases
      - DNA-(Apurinic or Apyrimidinic Site) Lyase: 96
  - DNA Repair Enzymes: 492
    - DNA-(Apurinic or Apyrimidinic Site) Lyase: 96

mouse Apex2 protein

Bio-Agent Context: Research Results