|1.||Lazarus, Philip: 5 articles (06/2014 - 08/2003)|
|2.||Radominska-Pandya, Anna: 3 articles (02/2013 - 01/2008)|
|3.||Dellinger, Ryan W: 3 articles (03/2010 - 06/2006)|
|4.||Chen, Gang: 3 articles (03/2010 - 06/2006)|
|5.||Muscat, Joshua E: 2 articles (06/2014 - 08/2003)|
|6.||Starlard-Davenport, Athena: 2 articles (07/2008 - 01/2008)|
|7.||Lyn-Cook, Beverly: 2 articles (07/2008 - 01/2008)|
|8.||Mackenzie, Peter I: 2 articles (12/2007 - 09/2004)|
|9.||Oztuzcu, Serdar: 1 article (08/2015)|
|10.||Bozgeyik, Esra: 1 article (08/2015)|
06/01/2014 - "UGT1A haplotype analysis found that the T-G haplotype in UGT1A10 exon 1 (block 2: rs17864678, rs10929251) decreased cancer risk for the colon [proximal (OR = 0.28, 95% CI = 0.11–0.69) and for the distal colon (OR = 0.32, 95% CI = 0.12–0.91)], and that the C-T-G haplotype in the 3′ region flanking the UGT1A shared exons (block 11: rs7578153, rs10203853, rs6728940) increased CRC risk in males (OR = 2.56, 95% CI = 1.10–5.95). "
02/01/2013 - "In summary, these studies suggest that extrahepatic UGT1A10 plays an important role in the metabolism and the bioactivation of C-1305 and constitutes the basis for further mechanistic studies on the mode of action of this drug, as well as translational studies on the role of this enzyme in regulation of C-1305 toxicity in cancer."
08/01/2015 - "Accordingly, UGT1A1, UGT1A8, and UGT1A10 were found to be upregulated, and UGT1A3, UGT1A5, UGT1A7, and UGT1A9 were downregulated in stomach tumors. "
06/01/2006 - "Together, these studies implicate UGT1A10 as an important detoxifier of polycyclic aromatic hydrocarbons in humans and that the UGT1A10 codon 139 polymorphism may be an important determinant in risk for tobacco-related cancers."
03/01/2010 - "UDP-glucuronosyltransferase 1A10: activity against the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and a potential role for a novel UGT1A10 promoter deletion polymorphism in cancer susceptibility."
07/01/2008 - "Differential down-regulation of UGT1A10 and UGT2B7 mRNAs, protein, and activity in breast carcinomas compared to the adjacent normal breast specimens from the same donor were also found. "
07/01/2008 - "Interestingly, in African American women, UGT1A10 expression was significantly decreased in breast carcinomas in comparison to normals (57+/-35 vs. 397+/-152, respectively; p<0.05). "
07/01/2008 - "Their overall expression was significantly decreased in breast carcinomas as compared to normal breast specimens (UGT1A10: 68+/-26 vs. 252+/-86, respectively; p<0.05) and (UGT2B7: 1.4+/-0.7 vs. 12+/-4, respectively; p<0.05). "
08/15/2003 - "In a case-control study of black individuals, a significant association with orolaryngeal carcinoma risk was found in persons with at least 1 UGT1A10(139Lys) allele (crude odds ratio, 0.29 [95% confidence interval, 0.10-0.81]; adjusted odds ratio, 0.20 [95% confidence interval, 0.05-0.87]). "
08/15/2003 - "Detection of UGT1A10 polymorphisms and their association with orolaryngeal carcinoma risk."
|3.||Breast Neoplasms (Breast Cancer)
01/01/2008 - "In the present study, we show for the first time that treatment of the MCF-7 ER-positive breast cancer cell line with E(2) produces a dose-dependent up-regulation of UGT1A10 mRNA levels, followed by a steady down-regulation. "
01/01/2008 - "The finding of E(2)-induced expression of UGT1A10 mRNA, followed by the down-regulation of UGT1A10 at pharmacological concentrations of E(2), might have a significant moderating effect on E(2) availability for ER and estrogen clearance, thereby promoting the signaling of E(2) in breast cancer cells."
01/01/2008 - "Collectively, these results suggest that induction of UGT1A10 mRNA expression by E(2) might be mediated through ER, and that this isoform is a novel, estrogen-regulated target gene in MCF-7, ER-positive human breast cancer cells. "
|4.||Colonic Neoplasms (Colon Cancer)
11/01/2007 - "These data suggest that UGT1A10 is the most active UGT against PhIP and N-OH-PhIP and that UGT1A10 may play an important role in susceptibility to HCA-induced colon cancer."
01/10/2006 - "RT-PCR was used to detect the mRNA expression of Nrf2, UGT1A, UGT1A8 and UGT1A10 in cells and the samples of human colon cancer tissue. "
05/01/2001 - "To evaluate the nature of LKM-3 antibodies, we screened sera from 80 untreated patients with autoimmune hepatitis (AIH) type 1 and 2, primary biliary cirrhosis (PBC), AIH/PBC, hepatitis C virus (HCV) infection, and 12 healthy individuals (controls) against 7 recombinant human UGT isoenzymes (UGT1A1, UGT1A4, UGT1A6, UGT1A7, UGT1A9, UGT1A10, and UGT2B7). "
|2.||Messenger RNA (mRNA)
|3.||Glucuronosyltransferase (UDP Glucuronosyltransferase)
|5.||Aromatic Polycyclic Hydrocarbons (Polycyclic Aromatic Hydrocarbons)
|7.||UGT1A8 UDP-glucuronosyltransferase (UGT1A8)