(N-propargyl-(3R) and (3S) aminoindan-5-yl)-ethyl methyl carbamate

antiparkinson-antialzheimer neuroprotective drug

Also Known As:

TV 3279; TV3279

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Indenes: 4
        Indans: 7
        (N-propargyl-(3R) and (3S) aminoindan-5-yl)-ethyl methyl carbamate: 6
- Carboxylic Acids: 973
  - Acyclic Acids
    - Carbamates: 945
      - (N-propargyl-(3R) and (3S) aminoindan-5-yl)-ethyl methyl carbamate: 6
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Indenes: 4
    - Indans: 7
      - (N-propargyl-(3R) and (3S) aminoindan-5-yl)-ethyl methyl carbamate: 6

Experts

1.	Amit, Tamar: 4 articles (06/2004 - 10/2002)
2.	Youdim, Moussa B H: 4 articles (06/2004 - 10/2002)
3.	Bar-Am, Orit: 3 articles (06/2004 - 10/2002)
4.	Yogev-Falach, Merav: 3 articles (06/2004 - 10/2002)
5.	Weinstock, Marta: 2 articles (05/2003 - 10/2002)
6.	Weinstock, M: 2 articles (12/2001 - 01/2000)
7.	Youdim, M B: 2 articles (12/2001 - 01/2000)
8.	Sagi, Yotam: 1 article (06/2004)
9.	Bar Am, Orit: 1 article (10/2003)
10.	Falach-Yogev, Merav: 1 article (10/2003)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 10/15/2003 - "These results have provided a new understanding into the mechanism of neuroprotective actions of rasagiline and its anti-Alzheimer drug derivatives TV3326 and TV3279, which are relevant for therapy of Parkinson's disease, Alzheimer's disease and other neurodegenerative diseases." 10/01/2002 - "Two novel neuroprotective cholinesterase (ChE) inhibitors, TV3326, (N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate, and TV3279, (N-propargyl-(3S) aminoindan-5-yl)-ethyl methyl carbamate, were derived from rasagiline for the treatment of Alzheimer's disease (AD). " 05/01/2003 - "Two novel neuroprotective cholinesterase (ChE) inhibitors, TV3326 and TV3279 [(N-propargyl-(3R) and (3S) aminoindan-5-yl)-ethyl methyl carbamate], respectively were derived from rasagiline, for the treatment of Alzheimer's disease (AD). " 12/01/2001 - "Introduction of a carbamate moiety into the rasagiline molecule to confer cholinesterase inhibitory activity for the treatment of Alzheimer's disease, resulted in compounds TV3326 [(N-Propargyl-(3R)Aminoindan-5-YL)-Ethyl Methyl Carbamate] and its S-enantiomer TV3279 [(N-Propargyl-(3S)Aminoindan-5-YL)-Ethyl Methyl Carbamate], which retain the neuroprotective activities of rasagiline and TVP1022. "
2.	Neuroblastoma 12/01/2001 - "Furthermore, rasagiline, TV3326 and TV3279 are able to influence the processing of amyloid precursor protein by activation of alpha-secretase and increasing the release of soluble alpha APP in rat PC-12 and human neuroblastoma SH-SY5Y cells and in rat and mice cortex and hippocampus. " 06/01/2004 - "We have recently shown that the anti-Parkinson-propargyl-containing monoamine oxidase B (MAO-B) inhibitor drug, rasagiline [N-propargyl-(1R)-aminoindan], and its cholinesterase inhibitor derivatives TV3326 and TV3279, regulate amyloid precursor protein (APP) processing by a protein kinase C (PKC)-dependent mechanism in SH-SY5Y neuroblastoma and PC12 cells. "
3.	Neurodegenerative Diseases (Neurodegenerative Disease) 10/15/2003 - "These results have provided a new understanding into the mechanism of neuroprotective actions of rasagiline and its anti-Alzheimer drug derivatives TV3326 and TV3279, which are relevant for therapy of Parkinson's disease, Alzheimer's disease and other neurodegenerative diseases."
4.	Closed Head Injuries 01/01/2000 - "TV3326 and TV3279 protect against ischemia-induced cytotoxicity in PC12 cells and reduce the oedema, deficits in motor function and memory after closed head injury in mice. "
5.	Parkinson Disease (Parkinson's Disease) 10/15/2003 - "These results have provided a new understanding into the mechanism of neuroprotective actions of rasagiline and its anti-Alzheimer drug derivatives TV3326 and TV3279, which are relevant for therapy of Parkinson's disease, Alzheimer's disease and other neurodegenerative diseases."

Related Drugs and Biologics

1.	(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate
2.	rasagiline (Azilect)
3.	Cholinesterases (Cholinesterase)
4.	N-propargyl
5.	methyl carbamate
6.	Proteins (Proteins, Gene)
7.	Amyloid (Amyloid Fibrils)
8.	Amyloid Precursor Protein Secretases (beta-Secretase)
9.	Protein Kinase C
10.	Monoamine Oxidase (MAO)

Related Therapies and Procedures

1.	Therapeutics