HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

SAR943

inhibits single allergen-induced allergic inflammation such as eosinophilic and lymphocytic infiltration and mRNA expression for interleukin (IL)-4 and IL-5

Also Known As:

32-deoxorapamycin

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Lactones: 1549
  - Macrolides: 4391
    - Sirolimus: 9779
      - SAR943: 2

Experts

1.	Chung, K Fan: 1 article (07/2003)
2.	Eynott, Paul R: 1 article (07/2003)
3.	Fozard, John R: 1 article (07/2003)
4.	Hannon, Jason P: 1 article (07/2003)
5.	Huang, Tung-Jung: 1 article (07/2003)
6.	Mazzoni, Lazzaro: 1 article (07/2003)
7.	Nicklin, Paul L: 1 article (07/2003)
8.	Oates, Timothy: 1 article (07/2003)
9.	Salmon, Michael: 1 article (07/2003)
10.	Schaeublin, Elisabeth: 1 article (07/2003)

Related Diseases

1.

Inflammation (Inflammations)

07/01/2003 - "Therefore, CsA and SAR943 have no effect on chronic eosinophilic inflammation, while SAR943, but not CsA, had a small effect on the proliferation of ASM and epithelium."
07/01/2003 - "We examined the effects of CsA and SAR943, administered orally, on asthmatic responses in a rat model of chronic allergic inflammation. "
07/01/2003 - "25 and 1 h prior to OA challenge) induced reductions in the BAL fluid parameters of inflammation; IMM125 and MLD987, at a dose of 1 mg kg(-1) had no significant effect whereas SAR943 reduced lymphocyte numbers. "
07/01/2003 - "Effects of cyclosporin A and a rapamycin derivative (SAR943) on chronic allergic inflammation in sensitized rats."
07/01/2003 - "Immunomodulators such as cyclosporin A (CsA) and SAR943 (32-deoxorapamycin) inhibit single allergen-induced allergic inflammation such as eosinophilic and lymphocytic infiltration and mRNA expression for interleukin (IL)-4 and IL-5. "

Related Drugs and Biologics

1.	Sirolimus (Rapamycin)
2.	Cyclosporine (Ciclosporin)
3.	Interleukin-5 (Interleukin 5)
4.	Messenger RNA (mRNA)
5.	Interleukins
6.	Immunologic Factors (Immunomodulators)
7.	Allergens
8.	MLD 987