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1- (5- (hydroxymethyl)bicyclo(3.1.0)hex- 3- en- 2- yl)- 5- methyl- 1,3- dihydropyrimidine- 2,4- dione

a conformationally locked stavudine analog; structure in first source

Also Known As:

L-N-MCd4T; N-MCD4T; hydroxymethyl-BCHMDPD

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Bridged-Ring Compounds: 1
      - Bridged Bicyclo Compounds
        1-(5-(hydroxymethyl)bicyclo(3.1.0)hex-3-en-2-yl)-5-methyl-1,3-dihydropyrimidine-2,4-dione: 1
Polycyclic Compounds: 6
- Bridged-Ring Compounds: 1
  - Bridged Bicyclo Compounds
    - 1-(5-(hydroxymethyl)bicyclo(3.1.0)hex-3-en-2-yl)-5-methyl-1,3-dihydropyrimidine-2,4-dione: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidine Nucleosides: 50
      - Thymidine: 4460
        1-(5-(hydroxymethyl)bicyclo(3.1.0)hex-3-en-2-yl)-5-methyl-1,3-dihydropyrimidine-2,4-dione: 1
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Pyrimidine Nucleosides: 50
    - Thymidine: 4460
      - 1-(5-(hydroxymethyl)bicyclo(3.1.0)hex-3-en-2-yl)-5-methyl-1,3-dihydropyrimidine-2,4-dione: 1
  - Deoxyribonucleosides: 34
    - Thymidine: 4460
      - 1-(5-(hydroxymethyl)bicyclo(3.1.0)hex-3-en-2-yl)-5-methyl-1,3-dihydropyrimidine-2,4-dione: 1

Experts

1.	Chun, Moon Woo: 1 article (11/2006)
2.	Jeong, Lak Shin: 1 article (11/2006)
3.	Kim, Kyung Ran: 1 article (11/2006)
4.	Moon, Hyung Ryong: 1 article (11/2006)
5.	Park, Ah-Young: 1 article (11/2006)

Related Diseases

1.

Acquired Immunodeficiency Syndrome (AIDS)

11/21/2006 - "L-N-MCd4T (1) has been synthesized as a potent anti-HIV agent starting from (R)-epichlorohydrin using tandem alkylation, chemoselective reduction of ester in the presence of lactone functional group, RCM reaction and Mitsunobu reaction as key steps and was found to be a very potent anti-HIV-1 (EC50 = 6.76 microg mL(-1)) agent without cytotoxicity up to 100 microg mL(-1), indicating that the anti-HIV-1 activity found is similar to that of ddI (EC50 = 4.95 microg mL(-1)), which is used clinically for the treatment of AIDS patients."

Related Drugs and Biologics

1.	Anti-HIV Agents (AIDS Drugs)
2.	Lactones
3.	Esters
4.	Epichlorohydrin (Epichlorhydrin)