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cinnoline

structure in first source

Also Known As:

hexahydrocinnoline

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - cinnoline: 9

Experts

1.	Abd-Elmonem, Mohamed: 1 article (01/2020)
2.	Abo-Elsebaa, Mohamed: 1 article (01/2020)
3.	Mekheimer, Ramadan Ahmed: 1 article (01/2020)
4.	Nazmy, Maiiada Hassan: 1 article (01/2020)
5.	Sadek, Kamal Usef: 1 article (01/2020)
6.	Shoman, Mai E: 1 article (01/2020)
7.	Barraja, Paola: 1 article (11/2014)
8.	Carbone, Anna: 1 article (11/2014)
9.	Cirrincione, Girolamo: 1 article (11/2014)
10.	Diana, Patrizia: 1 article (11/2014)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2020 - "Only cinnoline 4b stood out as the most potent cinnoline derivative (mean GI%=26.33) with broad-spectrum antitumor activity against the most tested cancer cell lines from all subpanels. " 11/26/2014 - "Derivatives of new ring systems 11H-pyrido[3',2':4,5]pyrrolo[3,2-c]cinnoline and pyrido[3',2':4,5]pyrrolo[1,2-c][1,2,3]benzotriazine have been prepared from the key intermediates 2-(1H-pyrrolo[2,3-b]pyridin-2-yl)anilines in excellent yields (94-99%) and screened by the National Cancer Institute (Bethesda, MD) on about 60 human tumor cell lines derived from nine cancer cell types. "
2.	Leukemia 01/01/2020 - "The target cinnoline 4b emerged as the most active derivative against both leukemia RPMI-8226 and melanoma LOX IMVI cell lines (GI% = 106.06 and 82.1) respectively, with IC50 values equal to 17.12 ± 1.31 and 12.32 ± 0.75 μg/mL, which are comparable to those of staurosporin; 24.97 ± 1.47 and 8.45 ± 0.42 μg/mL, respectively. " 07/15/1999 - "To obtain the indolobenzotriazine system it was necessary to protect the 3 position of the indole nucleus to avoid cyclization into the indolo[3,2-c]cinnoline system 4. Indolobenzotriazines 5a-g were evaluated in vitro for antitumor activity against a panel of leukemia-, lymphoma-, carcinoma-, and neuroblastoma-derived cell lines. "
3.	Infections 12/01/1951 - "A cinnoline compound ("528") for the treatment of Trypanosoma congolense infections." 04/17/1948 - "Cinnoline derivatives as chemotherapeutic agents for Trypanosoma congolense infections."
4.	Pyelonephritis 10/01/1974 - "The antimicrobial activity of cinoxacin, 1-ethyl-4(1H)-oxo-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid, previously reported as compound 64716, was determined and compared with other antimicrobial agents at a dosage of 12 mg/kg once daily in a descending pyelonephritis rat model with Escherichia coli and Proteus mirabilis as infecting organisms. "
5.	Pain (Aches) 02/10/2005 - "Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties."

Related Drugs and Biologics

1.	Quinoxalines
2.	Quinazolines
3.	Cinoxacin (Cinobac)
4.	Carcinogens
5.	Carboxylic Acids
6.	Anti-Infective Agents (Microbicides)
7.	Aniline Compounds
8.	phthalazine
9.	isoquinoline
10.	quinoline