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aculeatin A

antineoplastic from Amomum aculeatum; structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ketones: 2618
  - Cyclohexanones: 5
    - aculeatin A: 1
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Spiro Compounds: 2
      - aculeatin A: 1
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclohexanes: 3
        Cyclohexanones: 5
        aculeatin A: 1
Polycyclic Compounds: 6
- Spiro Compounds: 2
  - aculeatin A: 1

Experts

1.	Chai, Hee-Byung: 1 article (03/2008)
2.	Chin, Young-Won: 1 article (03/2008)
3.	Farnsworth, Norman R: 1 article (03/2008)
4.	Kardono, Leonardus B S: 1 article (03/2008)
5.	Kinghorn, A Douglas: 1 article (03/2008)
6.	Mi, Qiuwen: 1 article (03/2008)
7.	Riswan, Soedarsono: 1 article (03/2008)
8.	Ruskandi, Agus: 1 article (03/2008)
9.	Salim, Angela A: 1 article (03/2008)
10.	Su, Bao-Ning: 1 article (03/2008)

Related Diseases

1.	Lymphoid Leukemia 03/01/2008 - "Of these, aculeatin A ( 1; ED 50 0.2-1.0 microM) was found to be among the most cytotoxic of the compounds tested and was further evaluated in an in vivo hollow fiber assay; it was found to be active against MCF-7 (human breast cancer) cells implanted intraperitoneally at doses of 6.25, 12.5, 25, and 50 mg/kg. However, when 1 was tested using P388 lymphocytic leukemia and human A2780 ovarian carcinoma in vivo models, it was deemed to be inactive at the doses used."
2.	Carcinoma (Carcinomatosis) 03/01/2008 - "Of these, aculeatin A ( 1; ED 50 0.2-1.0 microM) was found to be among the most cytotoxic of the compounds tested and was further evaluated in an in vivo hollow fiber assay; it was found to be active against MCF-7 (human breast cancer) cells implanted intraperitoneally at doses of 6.25, 12.5, 25, and 50 mg/kg. However, when 1 was tested using P388 lymphocytic leukemia and human A2780 ovarian carcinoma in vivo models, it was deemed to be inactive at the doses used."
3.	Breast Neoplasms (Breast Cancer) 03/01/2008 - "Of these, aculeatin A ( 1; ED 50 0.2-1.0 microM) was found to be among the most cytotoxic of the compounds tested and was further evaluated in an in vivo hollow fiber assay; it was found to be active against MCF-7 (human breast cancer) cells implanted intraperitoneally at doses of 6.25, 12.5, 25, and 50 mg/kg. However, when 1 was tested using P388 lymphocytic leukemia and human A2780 ovarian carcinoma in vivo models, it was deemed to be inactive at the doses used."