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2- (4- methylpiperazin- 1- yl)- 5H- benzo(c)(1,5)naphthyridin- 6- one

structure in first source

Also Known As:

2-(4-methyl-piperazin-1-yl)-5H-benzo(c)(1,5)naphthyridin-6-one; 2-Mepip-BNO; GPI 16539; GPI-16539

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - 2-(4-methylpiperazin-1-yl)-5H-benzo(c)(1,5)naphthyridin-6-one: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Naphthyridines: 2
      - 2-(4-methylpiperazin-1-yl)-5H-benzo(c)(1,5)naphthyridin-6-one: 1

Experts

1.	Crisafulli, Concetta: 1 article (12/2005)
2.	Cuzzocrea, Salvatore: 1 article (12/2005)
3.	Di Paola, Rosanna: 1 article (12/2005)
4.	Ferrraris, Dana: 1 article (12/2005)
5.	Genovese, Tiziana: 1 article (12/2005)
6.	Mazzon, Emanuela: 1 article (12/2005)
7.	Muià, Carmelo: 1 article (12/2005)
8.	Xu, Weizheng: 1 article (12/2005)
9.	Zhang, Jie: 1 article (12/2005)

Related Diseases

1.	Shock 12/19/2005 - "Treatment with PARP-1 inhibitors, GPI 15427 or GPI 16539, ameliorates intestinal damage in rat models of colitis and shock." 12/19/2005 - "As inflammation is important in the development of colitis and ischemia/reperfusion (I/R) injury of the intestine, we investigated the effects of 10-(4-methyl-piperazin-1-ylmethyl)-2H-7-oxa-1,2-diaza-benzo[de]anthracen-3-one (GPI 15427) and 2-(4-methyl-piperazin-1-yl)-5H-benzo[c][1,5]naphthyridin-6-one (GPI 16539), two novel and potent inhibitors of PARP-1, in a rat model of gut injury and inflammation, splanchnic artery occlusion (SAO)shock and dinitrobenzene sulfonic acid (DNBS)-induced colitis. "
2.	Colitis 12/19/2005 - "Treatment with PARP-1 inhibitors, GPI 15427 or GPI 16539, ameliorates intestinal damage in rat models of colitis and shock." 12/19/2005 - "Thus, GPI 15427 and GPI 16539 exhibited anti-inflammation activity against damage caused by intestinal ischemia/reperfusion and colitis. " 12/19/2005 - "As inflammation is important in the development of colitis and ischemia/reperfusion (I/R) injury of the intestine, we investigated the effects of 10-(4-methyl-piperazin-1-ylmethyl)-2H-7-oxa-1,2-diaza-benzo[de]anthracen-3-one (GPI 15427) and 2-(4-methyl-piperazin-1-yl)-5H-benzo[c][1,5]naphthyridin-6-one (GPI 16539), two novel and potent inhibitors of PARP-1, in a rat model of gut injury and inflammation, splanchnic artery occlusion (SAO)shock and dinitrobenzene sulfonic acid (DNBS)-induced colitis. "
3.	Ischemia 12/19/2005 - "GPI 15427 and GPI 16539 may be useful for treating gut ischemia and inflammation." 12/19/2005 - "Thus, GPI 15427 and GPI 16539 exhibited anti-inflammation activity against damage caused by intestinal ischemia/reperfusion and colitis. " 12/19/2005 - "As inflammation is important in the development of colitis and ischemia/reperfusion (I/R) injury of the intestine, we investigated the effects of 10-(4-methyl-piperazin-1-ylmethyl)-2H-7-oxa-1,2-diaza-benzo[de]anthracen-3-one (GPI 15427) and 2-(4-methyl-piperazin-1-yl)-5H-benzo[c][1,5]naphthyridin-6-one (GPI 16539), two novel and potent inhibitors of PARP-1, in a rat model of gut injury and inflammation, splanchnic artery occlusion (SAO)shock and dinitrobenzene sulfonic acid (DNBS)-induced colitis. "
4.	Inflammation (Inflammations) 12/19/2005 - "GPI 15427 and GPI 16539 may be useful for treating gut ischemia and inflammation." 12/19/2005 - "Thus, GPI 15427 and GPI 16539 exhibited anti-inflammation activity against damage caused by intestinal ischemia/reperfusion and colitis. " 12/19/2005 - "As inflammation is important in the development of colitis and ischemia/reperfusion (I/R) injury of the intestine, we investigated the effects of 10-(4-methyl-piperazin-1-ylmethyl)-2H-7-oxa-1,2-diaza-benzo[de]anthracen-3-one (GPI 15427) and 2-(4-methyl-piperazin-1-yl)-5H-benzo[c][1,5]naphthyridin-6-one (GPI 16539), two novel and potent inhibitors of PARP-1, in a rat model of gut injury and inflammation, splanchnic artery occlusion (SAO)shock and dinitrobenzene sulfonic acid (DNBS)-induced colitis. "

Related Drugs and Biologics

1.	GPI 15427
2.	Sulfonic Acids
3.	Dinitrobenzenes
4.	2,4-dinitrofluorobenzene sulfonic acid