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Boc-D-FMK

Caspase inhibitor and neuroprotective agent

Networked: 6 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzyl Compounds: 2
        Boc-D-FMK: 6
  - Halogenated Hydrocarbons: 42
    - Fluorinated Hydrocarbons: 4
      - Boc-D-FMK: 6

Experts

1.	Baty, Roua S: 1 article (04/2022)
2.	Canbay, Ali: 1 article (02/2009)
3.	Hilken, Gero: 1 article (02/2009)
4.	Jaeckel, Sandra: 1 article (02/2009)
5.	Landgraeber, Stefan: 1 article (02/2009)
6.	Löer, Franz: 1 article (02/2009)
7.	Totsch, Martin: 1 article (02/2009)
8.	Wedemeyer, Christian: 1 article (02/2009)
9.	von Knoch, Marius: 1 article (02/2009)
10.	Bessho, Toshio: 1 article (01/2009)

Related Diseases

1.	Osteolysis 02/01/2009 - "The aim of the current study was to determine in a murine calvarial model of wear particle-induced osteolysis whether inhibition of apoptosis using the pan-caspase inhibitor BOC-D-FMK reduces aseptic loosening. "
2.	Leukemia 04/01/2022 - "The purpose of this study was to analyze if bosutinib (BOS) combined with Boc-D-FMK effectively suppressed proliferation and induced apoptosis in K562 cells to a lesser extent, implying that bosutinib is an effective leukemia treatment and that its combination with Boc-D-FMK is a mild chemotherapeutic agent against leukemia. "
3.	Neuroblastoma 07/07/1999 - "Furthermore, the pan-caspase enzyme inhibitor BOC-d-fmk prevented apoptosis, but not necrosis, and only partially decreased cytotoxicity induced by 4-HPR, indicating that 4-HPR induced both apoptosis and necrosis in neuroblastoma cells. " 11/01/2007 - "Neuroblastoma cells were treated with melphalan (L-PAM), fenretinide, 4-hydroperoxycyclophosphamide (4-HC)+/-pan-caspase inhibitor BOC-d-fmk, topotecan or with 10Gy gamma radiation+/-hydrogen peroxide (H2O2) and fixed immediately postradiation. "
4.	Virus Diseases (Viral Diseases) 01/01/2009 - "While virus proliferation was observed in both chorion and amnion cells, the virus infection resulted in LDH leakage, caspase-3 protein cleavage, and oligonucleosomal DNA fragmentation, all of which were observed only in the chorion cells and inhibited by the presence of Boc-D-fmk except for the virus proliferation. "
5.	Neoplasms (Cancer) 01/01/2004 - "We used the Karpas 299 and SU-DHL-1 cell lines, and the caspase inhibitors Boc-D-FMK and DEVD-FMK to investigate the role of caspase-3 activation in tumor cell death after treatment with doxorubicin. "

Related Drugs and Biologics

1.	Caspases
2.	bosutinib
3.	Caspase 3 (Caspase-3)
4.	Fenretinide
5.	Caspase Inhibitors
6.	Topotecan (Hycamtin)
7.	Proteins (Proteins, Gene)
8.	Melphalan (Alkeran)
9.	Hydrogen Peroxide (Hydroperoxide)
10.	Enzyme Inhibitors (Inhibitors, Enzyme)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)