|1.||Lee, Chulho: 2 articles (09/2015 - 06/2014)|
|2.||Yang, Jee Sun: 2 articles (09/2015 - 06/2014)|
|3.||Han, Gyoonhee: 2 articles (09/2015 - 06/2014)|
|4.||Sundby, Eirik: 1 article (01/2016)|
|5.||Hoff, Bård Helge: 1 article (01/2016)|
|6.||Moen, Ingri Ullestad: 1 article (01/2016)|
|7.||Skjønsfjell, Ellen Martine: 1 article (01/2016)|
|8.||Jurisch-Yaksi, Nathalie: 1 article (01/2016)|
|9.||Buene, Audun Formo: 1 article (01/2016)|
|10.||Bugge, Steffen: 1 article (01/2016)|
01/01/2016 - "Finally, the most promising thienopyrimidine drug was evaluated in a panel of human cancer cell lines, showing a clear potential for thienopyrimidines as anti-cancer agents. "
07/01/2013 - "A thienopyrimidine derivative induces growth inhibition and apoptosis in human cancer cell lines via inhibiting Aurora B kinase activity."
02/01/2009 - "Isomeric thienopyrimidine cores were evaluated as isosteres for a 4-anilinoquinazoline core and several analogs containing the thieno[3,2-d]pyrimidine core showed anti-proliferative activity with IC(50) values less than 1 microM against human tumor cells in vitro."
03/15/2010 - "Here, we discuss the case history of the discovery and properties of an increasingly used chemical probe, the pan-class I PI3K and mammalian target of rapamycin (mTOR) inhibitor PI-103 (a pyridofuropyrimidine), and its very recent evolution into the thienopyrimidine drug GDC-0941, which exhibits excellent oral anticancer activity in preclinical models and is now undergoing phase I clinical trials in cancer patients. "
|2.||Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
09/01/2015 - "Based on the results, Fms-like tyrosine kinase 3 was found to be the target for thienopyrimidine derivatives, and was confirmed to be a potent inhibitor for acute myeloid leukemia. "
06/15/2014 - "The thienopyrimidine-based analogues were subsequently screened for a target kinase, and FLT3, which is a potential target for acute myeloid leukemia (AML), was identified. "
|3.||Colorectal Neoplasms (Colorectal Cancer)
|4.||Neuralgia (Stump Neuralgia)
12/01/2013 - "A novel series of thienopyrimidine derivatives bearing various substituents or linked to various heterocyclic moieties through atoms spacers were prepared starting from 5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6- carboxamide potassium salt 3. Twelve out of the prepared compounds were selected and evaluated for their antiinflammatory activity using the formalin-induced paw edema and the turpentine oil-induced granuloma pouch bioassays using diclofenac sodium as a reference standard. "
|2.||fms-Like Tyrosine Kinase 3
|10.||Diclofenac (SR 38)