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hydroxytamoxifen

an estrogen antagonist
Networked: 61 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Jaouen, Gérard: 7 articles (09/2013 - 08/2003)
2. Vessières, Anne: 7 articles (09/2013 - 08/2003)
3. Top, Siden: 6 articles (01/2011 - 08/2003)
4. Leclercq, Guy: 5 articles (05/2010 - 08/2003)
5. Laïos, Ioanna: 4 articles (05/2010 - 08/2003)
6. Toillon, Robert-Alain: 3 articles (09/2013 - 11/2003)
7. Huché, Michel: 3 articles (11/2006 - 11/2003)
8. Corbet, Cyril: 2 articles (09/2013 - 05/2010)
9. Pigeon, Pascal: 2 articles (09/2013 - 04/2005)
10. Efremenko, Irena: 2 articles (01/2011 - 06/2009)

Related Diseases

1. Breast Neoplasms (Breast Cancer)
2. Neoplasms (Cancer)
11/01/2006 - "We recently reported the dual (antihormonal and cytotoxic) functionality of ferrocifens, which are organometallic complexes derived from hydroxytamoxifen, the standard molecule in the treatment of hormone-dependent breast cancers. "
12/01/2002 - "In contrast, the oxidized forms of some cancer-preventive agents, such as polyphenolics (ellagic acid, 4-hydroxytamoxifen and curcumin) and selenocompounds, can inactivate PKC by oxidizing the vicinal thiols present within the catalytic domain. "
05/01/1989 - "The steroid hormone receptor content of 32 malignant ovarian tumors was compared with the in vitro effectiveness of 4 hydroxytamoxifen (OH-TAM) and medroxy-progesterone acetate (MPA) tested in the Human Tumor Colony Forming Assay (HTCFA). "
08/04/2003 - "The goal of our study was to potentiate the effects of the ((R,R)-trans-1,2-diaminocyclohexane)-platinum(II) fragment [(DACH)Pt], known for its cytotoxic properties, either with tamoxifen (Tam), the most widely used antiestrogen in the treatment of hormone-dependent breast cancers, or with its active metabolite hydroxytamoxifen (hydroxy-Tam). "
11/29/1994 - "To analyse further which of these targets are primarily involved in the antiproliferative activity of these drugs against human breast cancers, two cell clones, namely the RTx6 and LY-2 variants, selected from MCF-7 cells for their resistance to high doses of tamoxifen (TAM) and the Keoxifen (KEO) analog LY 117018, respectively, were studied for their sensitivity to hydroxytamoxifen (OH-TAM) and KEO as well as the strong calmodulin antagonist calmidazolium. "
3. Endometrial Neoplasms (Endometrial Cancer)
4. Hepatocellular Carcinoma (Hepatoma)
5. Neurodegenerative Diseases (Neurodegenerative Disease)

Related Drugs and Biologics

1. Tamoxifen
2. Estrogen Receptor Modulators (Antiestrogen)
3. Estrogens (Estrogen)
4. Hormones
5. Raloxifene (Evista)
6. Fluorescent Dyes (Fluorescent Probes)
7. Carbon Monoxide
8. 1,2-cyclohexanediamine (dach)
9. N-desmethyltamoxifen
10. Estradiol (Estrace)