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4- (3,4,5- trimethoxyphenyl)- 6- (2,4,5- trimethoxyphenyl)- 2- diethylaminopyrimidine

structure in first source

Also Known As:

TAS-202

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - 4-(3,4,5-trimethoxyphenyl)-6-(2,4,5-trimethoxyphenyl)-2-diethylaminopyrimidine: 2

Experts

1.	Kimura, Ikuko: 2 articles (04/2003 - 02/2002)
2.	Kiniwa, Mamoru: 2 articles (04/2003 - 02/2002)
3.	Kuraishi, Yasushi: 2 articles (04/2003 - 02/2002)
4.	Suzuki, Takashi: 2 articles (04/2003 - 02/2002)
5.	Tanaka, Katsunao: 2 articles (04/2003 - 02/2002)
6.	Watanabe, Motomu: 1 article (04/2003)
7.	Konno, Yasuo: 1 article (02/2002)

Related Diseases

1.	Inflammation (Inflammations) 04/11/2003 - "These results, together with the observation that TAS-202 in combination with indomethacin or prednisolone maintained its ability to exert an antiangiogenic effect, indicate that TAS-202 may offer promise as an oral pro-drug for the treatment of rheumatoid arthritis, through its inhibitory effect on angiogenesis at the inflammation site."
2.	Rheumatoid Arthritis 04/11/2003 - "These results, together with the observation that TAS-202 in combination with indomethacin or prednisolone maintained its ability to exert an antiangiogenic effect, indicate that TAS-202 may offer promise as an oral pro-drug for the treatment of rheumatoid arthritis, through its inhibitory effect on angiogenesis at the inflammation site."
3.	Experimental Arthritis 02/25/2002 - "TAS-202 inhibited the proliferation of vascular endothelial cells more potently than magnosalin, and when given orally it inhibited basic fibroblast growth factor (bFGF)-induced angiogenesis and collagen-induced arthritis in mice. "
4.	Arthritis (Polyarthritis) 04/11/2003 - "Peroral TAS-202 reduced vessel density in rats with adjuvant-induced arthritis."

Related Drugs and Biologics

1.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
2.	Prodrugs
3.	Prednisolone (Predate)
4.	Indomethacin (Indometacin)
5.	magnosalin