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4- (methylnitrosamino)- 1- (3- pyridyl)- 1- butan- 1- ol

structure in first source
Also Known As:
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol; NNAL cpd
Networked: 19 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Hecht, Stephen S: 8 articles (08/2015 - 03/2008)
2. Stepanov, Irina: 5 articles (08/2015 - 09/2011)
3. Yuan, Jian-Min: 5 articles (05/2014 - 09/2011)
4. Benowitz, Neal L: 4 articles (09/2015 - 08/2009)
5. Carmella, Steven G: 4 articles (08/2015 - 03/2008)
6. Calfee, Carolyn S: 3 articles (09/2015 - 01/2011)
7. Jacob, Peyton: 3 articles (09/2015 - 08/2009)
8. Matthay, Michael A: 3 articles (09/2015 - 01/2011)
9. Nelson, Heather H: 3 articles (08/2015 - 11/2011)
10. Wang, Renwei: 3 articles (05/2014 - 09/2011)

Related Diseases

1. Lung Neoplasms (Lung Cancer)
04/01/2007 - "The UDP-glucuronosyltransferase 2B17 gene deletion polymorphism: sex-specific association with urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronidation phenotype and risk for lung cancer."
03/15/2012 - "Urinary metabolites of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronides, termed total NNAL, have recently been shown to be good predictors of lung cancer risk, years before diagnosis. "
07/27/2001 - "Nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) play a crucial role in the induction of lung cancer, and NNAL-O-glucuronide formation and elimination are important steps in detoxification of these compounds. "
01/15/2014 - "The following urinary metabolites were associated with lung cancer risk, independent of smoking intensity and duration: cotinine plus its glucuronide, a biomarker of nicotine uptake; 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides (total NNAL), a biomarker of the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK); and r-1-,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene (PheT), a biomarker of polycyclic aromatic hydrocarbons (PAH). "
11/01/2011 - "In this study, we quantified prediagnostic urinary levels of r-1,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene (PheT), a validated biomarker of PAH uptake and metabolism, as well as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides (total NNAL), and cotinine and its glucuronides (total cotinine), validated biomarkers of uptake of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, and nicotine, respectively, in relation to lung cancer risk among current smokers in a nested case-control study within a cohort of 18,244 Chinese men in Shanghai, China. "
2. Neoplasms (Cancer)
05/01/2008 - "4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) is an important tobacco-specific nitrosamine (TSNA) in the etiology of tobacco-related cancers, and N-glucuronidation is an important mechanism of NNAL detoxification. "
09/01/1997 - "To gain insight into the mechanism of PEITC lung tumor inhibition, we examined, in male F344 rats, the effects of dietary PEITC (3 micromol/g NIH-07 diet) in combination with NNK treatment (1.76 mg/kg, s.c., three times a week) for 4, 12 and 20 weeks on liver and lung microsomal metabolism of NNK and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), a major metabolite of NNK and also a lung carcinogen. "
03/01/2010 - "UDP-glucuronosyltransferase 1A10: activity against the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and a potential role for a novel UGT1A10 promoter deletion polymorphism in cancer susceptibility."
12/01/1989 - "The activity and distribution of the metabolic pathways of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), its major metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and the structurally related nitrosamine, N'-nitrosonornicotine (NNN) were examined in pulmonary cells from F344 rats in order to investigate the mechanisms by which NNK and NNAL, but not NNN, cause lung tumors. "
06/28/2013 - "Using a prospective study design comparing biomarker levels in cancer cases and controls, all of whom were smokers, the results demonstrate that several of these biomarkers - total cotinine, total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), r-1-,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene (PheT), and total N'-nitrosonornicotine (NNN) - are biomarkers of cancer risk. "
3. Esophageal Neoplasms (Esophageal Cancer)
4. Chronic Obstructive Pulmonary Disease (COPD)
5. Sepsis (Septicemia)

Related Drugs and Biologics

1. Cotinine
2. 4- (N- methyl- N- nitrosamino)- 1- (3- pyridyl)- 1- butanone
3. Glucuronides
4. Nicotine
5. Biological Markers (Surrogate Marker)
6. r- 1,t- 2,3,c- 4- tetrahydroxy- 1,2,3,4- tetrahydrophenanthrene
7. N'-nitrosonornicotine (nitrosonornicotine)
8. Glucuronosyltransferase (UDP Glucuronosyltransferase)
9. Tobacco Smoke Pollution (Passive Smoking)
10. 4- ((methylnitrosoamino)- 1- (3- pyridyl)but- 1- yl)beta- omega- glucosiduronic acid