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5-methylhept-2-en-4-one

isolated from hazelnut fruits

Also Known As:

(E)-5-methylhept-2-en-4-one; filbertone

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Acyclic Hydrocarbons
    - Alkanes: 241
      - Heptanes: 70
        5-methylhept-2-en-4-one: 2

Experts

1.	Kang, Wesuk: 1 article (07/2019)
2.	Moon, Youna: 1 article (07/2019)
3.	Park, Taesun: 1 article (07/2019)
4.	Tong, Tao: 1 article (07/2019)

Related Diseases

1.	Neurodegenerative Diseases (Neurodegenerative Disease) 01/01/2023 - "In conclusion, filbertone may show promise as a potential therapeutic for neurodegenerative disease." 01/01/2023 - "Activation of ROS-PERK-TFEB by filbertone ameliorates neurodegenerative diseases via enhancing the autophagy-lysosomal pathway."
2.	Neuroblastoma 01/01/2023 - "Here, we report that filbertone activates PERK through mitochondrial reactive oxygen species production, resulting in the increased nuclear translocation of transcription factor-EB in SH-SY5Y human neuroblastoma cells. "
3.	Inflammation (Inflammations) 01/01/2023 - "We previously reported that inhibition of hypothalamic inflammation by filbertone is mediated by suppression of nuclear factor kappa-B. "
4.	Body Weight (Weight, Body) 07/30/2019 - "We found that filbertone supplementation resulted in significant reductions in body weight gain and lipid accumulation in adipose tissue, with parallel improvements in plasma lipid levels (triglycerides, total cholesterol, and free fatty acids) and proinflammatory cytokines (interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α)). "

Related Drugs and Biologics

1.	Reactive Oxygen Species (Oxygen Radicals)
2.	NF-kappa B (NF-kB)
3.	Cytokines
4.	Interleukin-6 (Interleukin 6)
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	Triglycerides (Triacylglycerol)
7.	Transcription Factors (Transcription Factor)
8.	Lipids
9.	Nonesterified Fatty Acids (NEFA)
10.	Cholesterol