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RS 39604

Also Known As:

1-(4-amino-5-chloro-2-(3,5-dimethoxyphenil)methyloxy)-3-(1-(2-methylsulfonylamino)piperidin-4-yl)propan-1-one hydrochloride

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - RS 39604: 2
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Acyclic Hydrocarbons
    - Alkanes: 241
      - Propane: 265
        RS 39604: 2

Experts

1.	Alsasua, A: 1 article (07/2002)
2.	Goicoechea, C: 1 article (07/2002)
3.	Martín, M I: 1 article (07/2002)
4.	Pascual, D: 1 article (07/2002)

Related Diseases

1.	Visceral Pain 07/01/1995 - "SB 204070 behaved as an unsurmountable antagonist in this assay.7. In a model of visceral pain in conscious rats, RS 39604 (0.01-1 mg kg-1, i.v.) did not affect colorectal distension-induced increases in arterial pressure whereas morphine (1 mg kg-1, i.v.) produced significant inhibition of the response, implying that 5-HT4 receptors are not involved in nociception in this model.8. The data suggest that RS 39604 is a high affinity and selective 5-HT4 receptor antagonist that is orally active and long-lasting in vivo. "
2.	Tachycardia (Tachyarrhythmias) 07/01/1995 - "4. In anaesthetized vagotomized micropigs, RS 39604, administered by the i.v. or intraduodenal (i.duod.) route, produced dose-dependent inhibition of 5-HT-induced tachycardia (ID50 = 4.7 micrograms kg-1, i.v. and 254.5 micrograms kg-1, i.duod). "
3.	Diarrhea 07/05/2002 - "5-HTP (10 mg/kg) produced diarrhea that was significantly inhibited after pretreatment with ondansetron (5-HT(3) antagonist) or RS 39604 (5-HT(4) antagonist) (1-5 mg/kg). "

Related Drugs and Biologics

1.	5-HT4 Serotonin Receptors
2.	Ondansetron (Zofran)
3.	Morphine (MS Contin)
4.	5-Hydroxytryptophan (5 Hydroxytryptophan)
5.	SB 204070A