SS1(dsFv)PE38

recombinant antimesothelin immunotoxins against human gynecologic cancers grown in organotypic culture in vitro

Also Known As:

SS1P immunotoxin

Networked: 10 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Monoclonal Antibodies: 56412
        SS1(dsFv)PE38: 10
    - Immunoproteins: 43
      - Immunoglobulins: 30480
        Antibodies: 133716
        Monoclonal Antibodies: 56412
        SS1(dsFv)PE38: 10
  - Globulins: 3062
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Monoclonal Antibodies: 56412
        SS1(dsFv)PE38: 10

Experts

1.	Pastan, Ira: 7 articles (11/2018 - 11/2002)
2.	Hassan, Raffit: 7 articles (04/2016 - 11/2002)
3.	Ho, Mitchell: 2 articles (01/2013 - 03/2007)
4.	Onda, Masanori: 2 articles (10/2007 - 03/2007)
5.	King, Emily M: 1 article (11/2018)
6.	Leshem, Yasmin: 1 article (11/2018)
7.	Mazor, Ronit: 1 article (11/2018)
8.	Reiter, Yoram: 1 article (11/2018)
9.	Alewine, Christine: 1 article (04/2016)
10.	Cowan, Morgan L: 1 article (04/2016)

Related Diseases

1.	Neoplasms (Cancer) 11/14/2018 - "SS1P Immunotoxin Induces Markers of Immunogenic Cell Death and Enhances the Effect of the CTLA-4 Blockade in AE17M Mouse Mesothelioma Tumors." 11/01/2002 - "The objective of this study was to determine the antitumor activity of SS1(dsFv)PE38, a recombinant antimesothelin immunotoxin, against human gynecologic tumors grown in short-term culture in vitro. " 11/01/2002 - "Tumors expressing mesothelin showed a significant dose-dependent sensitivity to SS1(dsFv)PE38 even at concentrations as low as 1 ng/ml, whereas no antitumor activity was seen at 100 ng/ml in tumors that did not express mesothelin. " 01/01/2013 - "The immunocytokine retained sufficient bioactivity of IL12 and significantly inhibited human malignant mesothelioma (NCI-H226) grown in the peritoneal cavity of nude mice and showed comparable anti-tumor activity to that of the SS1P immunotoxin. " 05/01/2004 - "High expression of mesothelin is seen on tumor cells of patients with peritoneal mesothelioma and correlates with sensitivity to SS1(dsFv)PE38. "
2.	Mesothelioma 05/01/2004 - "Clinical studies of SS1(dsFv)PE38 in patients with peritoneal mesotheliomas are ongoing." 10/23/2013 - "The SS1P immunotoxin is combined with immunomodulatory therapy in order to improve its efficacy in human mesothelioma (Hassan et al., this issue). " 11/14/2018 - "SS1P Immunotoxin Induces Markers of Immunogenic Cell Death and Enhances the Effect of the CTLA-4 Blockade in AE17M Mouse Mesothelioma Tumors." 05/01/2004 - "High expression of mesothelin is seen on tumor cells of patients with peritoneal mesothelioma and correlates with sensitivity to SS1(dsFv)PE38. " 05/01/2004 - "Cytotoxic activity of the recombinant anti-mesothelin immunotoxin, SS1(dsFv)PE38, towards tumor cell lines established from ascites of patients with peritoneal mesotheliomas."
3.	Malignant Mesothelioma 01/01/2013 - "The immunocytokine retained sufficient bioactivity of IL12 and significantly inhibited human malignant mesothelioma (NCI-H226) grown in the peritoneal cavity of nude mice and showed comparable anti-tumor activity to that of the SS1P immunotoxin. " 11/01/2014 - "The primary objective of this study was to determine the safety and maximum tolerated dose (MTD) of the antimesothelin immunotoxin SS1(dsFv)PE38 (SS1P) (a recombinant antimesothelin immunotoxin consisting of a murine antimesothelin variable antibody fragment [Fv] linked to PE38, a truncated portion of Pseudomonas exotoxin A) in combination with pemetrexed and cisplatin in chemotherapy-naive patients with advanced malignant pleural mesothelioma (MPM). "
4.	Stomach Neoplasms (Stomach Cancer) 04/01/2016 - "In addition, the AGS gastric cancer cell line was tested for sensitivity to SS1(dsFv)PE38, a mesothelin-targeting immunotoxin. "
5.	Lung Neoplasms (Lung Cancer) 03/01/2007 - "The SS1P immunotoxin specific for mesothelin was assessed for its cytotoxic activity against lung cancer cells. "

Related Drugs and Biologics

1.	Immunotoxins (Immunotoxin)
2.	Exotoxins
3.	Immunoglobulin Variable Region
4.	Cisplatin (Platino)
5.	Pemetrexed (MTA)
6.	Mesothelin
7.	Sialic Acid Binding Ig-like Lectin 2
8.	Interleukin-12 (IL 12)
9.	Paraffin
10.	Gels

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Immunomodulation