tubacin

inhibits histone deacetylase 6; structure in first source

Also Known As:

octanediamide, N1-(4-((2R,4R,6S)-4-(((4,5-diphenyl-2-oxazolyl)thio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-dioxan-2-yl)phenyl)-N8-hydroxy-, rel-

Networked: 25 relevant articles (3 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Bradner, James E: 3 articles (08/2011 - 09/2008)
2.	Ikeda, Alan K: 2 articles (08/2011 - 07/2008)
3.	Lin, Tara: 2 articles (08/2011 - 07/2008)
4.	Mazitschek, Ralph: 2 articles (08/2011 - 06/2009)
5.	Rodriguez-Gonzalez, Agustin: 2 articles (08/2011 - 07/2008)
6.	Sakamoto, Kathleen M: 2 articles (08/2011 - 07/2008)
7.	Han, Mingming: 1 article (01/2021)
8.	Nakano, Mitsunori: 1 article (01/2021)
9.	Nomura, Yohei: 1 article (01/2021)
10.	Pandey, Deepesh: 1 article (01/2021)

Related Diseases

1.	Cysts 01/01/2016 - "Treatment with tubacin prevented cyst formation in MDCK cells, an in vitro model of cystogenesis. " 01/01/2016 - "Here we studied the effect of tubacin, a specific HDAC6 inhibitor, on cyst growth in polycystic kidney disease. " 01/01/2016 - "We also found that tubacin reduced cyst growth by inhibiting proliferation of cyst-lining epithelial cells, downregulated cyclic AMP levels, and improved renal function in a Pkd1-conditional mouse model of ADPKD. " 03/01/2014 - "Furthermore, pharmacological inhibition of HDAC6 by Tubastatin-A, Tubacin, and ACY-1215 decreased proliferation of cystic cholangiocytes in a dose- and time-dependent manner, and inhibited cyst growth in three-dimensional cultures. "
2.	Stroke (Strokes) 12/20/2019 - "Furthermore, we found that tubacin-induced up-regulation in eNOS expression in vivo is associated with improved endothelial function in diabetic db/db mice and with a marked attenuation of ischemic brain injury in a murine stroke model. "
3.	Autosomal Dominant Polycystic Kidney (ADPKD) 01/01/2016 - "We also found that tubacin reduced cyst growth by inhibiting proliferation of cyst-lining epithelial cells, downregulated cyclic AMP levels, and improved renal function in a Pkd1-conditional mouse model of ADPKD. "
4.	Brain Injuries (Brain Injury) 12/20/2019 - "Furthermore, we found that tubacin-induced up-regulation in eNOS expression in vivo is associated with improved endothelial function in diabetic db/db mice and with a marked attenuation of ischemic brain injury in a murine stroke model. "
5.	Urinary Bladder Neoplasms (Bladder Cancer) 03/01/2012 - "Taken together, we conclude that HDAC6 and SIRT2 work synergistically to promote cell migration and invasion in bladder cancer, and the HDAC6-specific inhibitor tubacin may be regarded as a novel therapeutic agent for bladder cancer."

Related Drugs and Biologics

1.	Sirtuin 2
2.	Cyclic AMP (AMP, Cyclic)
3.	Histone Deacetylase Inhibitors
4.	trichostatin A (A 300)
5.	Histone Deacetylases (Histone Deacetylase)
6.	Histone Deacetylase 6
7.	theasinensin A
8.	Valproic Acid (Depakote)
9.	Messenger RNA (mRNA)
10.	17- (dimethylaminoethylamino)- 17- demethoxygeldanamycin

Related Therapies and Procedures

1.	Therapeutics
2.	Intraperitoneal Injections