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onjisaponin B

structure in first source

Networked: 6 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycosides: 2119
  - Saponins: 2867
    - onjisaponin B: 6
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - onjisaponin B: 6

Experts

1.	Law, Betty Yuen-Kwan: 2 articles (11/2015 - 11/2013)
2.	Liu, Liang: 2 articles (11/2015 - 11/2013)
3.	Wong, Vincent Kam-Wai: 2 articles (11/2015 - 11/2013)
4.	Wu, An-Guo: 2 articles (11/2015 - 11/2013)
5.	Hur, Jonghyun: 1 article (01/2021)
6.	Kim, Joonki: 1 article (01/2021)
7.	Kim, Min Cheol: 1 article (01/2021)
8.	Lee, Chang Hwan: 1 article (01/2021)
9.	Li, Huan: 1 article (01/2021)
10.	Tran, Huynh Nguyen Khanh: 1 article (01/2021)

Related Diseases

1.	Parkinson Disease (Parkinson's Disease) 01/01/2020 - "The onjisaponin B metabolite tenuifolin ameliorates dopaminergic neurodegeneration in a mouse model of Parkinson's disease." 11/15/2013 - "Further investigation showed that among three single components derived from Radix Polygalae--i.e., polygalacic acid, senegenin and onjisaponin B--onjisaponin B was able to induce autophagy and accelerate both the removal of mutant huntingtin and A53T α-synuclein, which are highly associated with Huntington disease and Parkinson disease, respectively. "
2.	Neurodegenerative Diseases (Neurodegenerative Disease) 01/01/2020 - "Onjisaponin B (OB) is the main active ingredient of the traditional Chinese medicinal herb polygala, which is effective against neurodegenerative disorders. "
3.	Parkinsonian Disorders (Parkinsonism) 01/01/2021 - "Our study suggests that relief of Parkinsonism symptoms and rescue of tyrosine hydroxylase activity in dopaminergic neurons are affected by autophagy enhancing effect of WIN-1001X which the onjisaponin B is one of the major components of activity."
4.	Sleep Initiation and Maintenance Disorders (Insomnia) 11/24/2015 - "With its traditional use in relieving insomnia and anxiety, our previous study has identified onjisaponin B from Radix Polygalae (RP), as a novel autophagic enhancer with potential neuroprotective effects. "
5.	Cognitive Dysfunction 03/01/2018 - "Onjisaponin B prevents cognitive impairment in a rat model of D-galactose-induced aging." 01/01/2016 - "Traditional Chinese Nootropic Medicine Radix Polygalae and Its Active Constituent Onjisaponin B Reduce β-Amyloid Production and Improve Cognitive Impairments."

Related Drugs and Biologics

1.	tenuifolin diterpene
2.	Neuroprotective Agents
3.	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)
4.	Synucleins
5.	Nootropic Agents (Nootropics)
6.	Galactose (Galactopyranose)
7.	Amyloid (Amyloid Fibrils)
8.	tenuigenin
9.	polygalacic acid