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chlorotriphenylphosphine- 1,3- bis(diphenylphosphino)propanegold(I)

structure in first source

Also Known As:

Cl3PhP-b2PhPPAu

Networked: 2 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Organometallic Compounds: 64
  - Organogold Compounds
    - chlorotriphenylphosphine-1,3-bis(diphenylphosphino)propanegold(I): 2

Experts

1.	Caruso, Francesco: 2 articles (03/2008 - 03/2007)
2.	Paduano, Francesco: 2 articles (03/2008 - 03/2007)
3.	Pettinari, Claudio: 2 articles (03/2008 - 03/2007)
4.	Rossi, Miriam: 2 articles (03/2008 - 03/2007)
5.	Villa, Raffaella: 2 articles (03/2008 - 03/2007)
6.	Marchetti, Fabio: 1 article (03/2008)
7.	Monti, Elena: 1 article (03/2008)
8.	Daidone, Maria Grazia: 1 article (03/2007)
9.	Pennati, Marzia: 1 article (03/2007)
10.	Zaffaroni, Nadia: 1 article (03/2007)

Related Diseases

1.

Melanoma (Melanoma, Malignant)

03/27/2008 - "(31)P nuclear magnetic resonance and electrospray ionization-mass spectrometry studies on the melanoma cytotoxic chlorotriphenylphosphine-1,3-bis(diphenylphosphino)propanegold(I), [Au(DPPP)(PPh 3)Cl], show partial decomposition that includes the novel dinuclear cation [Au 2(DPPP) 2Cl] (+); its structure was calculated by using the density functional theory (DFT). "
03/15/2007 - "Overall, results from the study indicate that chlorotriphenylphosphine-1,3-bis(diphenylphosphino)propanegold(I) markedly inhibits melanoma cell growth by inducing mitochondria-mediated apoptosis and suggest it as a good candidate for additional evaluation as an anticancer agent against melanoma."
03/15/2007 - "Based on previous evidence indicating a selective cytotoxic activity of the mixed phosphine gold complex chlorotriphenylphosphine-1,3-bis(diphenylphosphino)propanegold(I) for melanoma cells, we investigated the cellular bases of its antiproliferative effect in a panel of human melanoma cell lines (JR8, SK-Mel-5, Mel-501, 2/60, 2/21 and GRIG). "
03/15/2007 - "Mitochondria are primary targets in apoptosis induced by the mixed phosphine gold species chlorotriphenylphosphine-1,3-bis(diphenylphosphino)propanegold(I) in melanoma cell lines."

Related Drugs and Biologics

1.	Cations
2.	Antineoplastic Agents (Antineoplastics)
3.	Gold
4.	phosphine (phosphane)